Fig. 1

Effects of P. distasonis on T2D-related indicators in SD rats. A The overall animal experimental workflow. B Dynamic changes in body weight in rats (n = 8 per group); C: Fasted blood glucose in rats at week 12 (n = 8 per group). D Glycated serum protein in rats at week 12 (n = 8 per group). E Insulin resistance index in rats at week 12 (n = 8 per group). F and G Plasma glucose profile and mean area under the curve (AUC) measured during an oral glucose tolerance test at week 12 (n = 6 per group). H Representative images of H&E staining of the pancreas and kidney. (n = 6 per group), a: islet tissue, b: renal tubular epithelial cells, c: renal stroma. All differences were assessed by the Mann–Whitney U test. Significance was established at adjusted P < 0.05 with a false discovery rate (FDR) of 0.05. Data are expressed as mean ± SEM