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Fig. 3 | BMC Biology

Fig. 3

From: Indoleacrylic acid produced by Parabacteroides distasonis alleviates type 2 diabetes via activation of AhR to repair intestinal barrier

Fig. 3

Protective effects of P. distasonis against T2D on colon barrier disruption in rats. A Relative mRNA expression of Occludin, Claudin-1, Claudin-2, and ZO-1 proteins in colon tissue of rats (n = 8 per group). Each dot shows the value from each independent replicate. B Representative Western blot and densitometric analyses of Occludin, Claudin-1, Claudin-2, and ZO-1 proteins in colon tissue of rats (n = 6 per group). Each dot shows the value from each independent replicate. C Representative pictures of immunohistochemical staining for Claudin-1 and ZO-1 on colon tissue (n = 6 per group). (After DAB staining, the positive antibody reaction was brown. After restaining with hematoxylin, the nuclei were blue). Data are expressed as mean ± SEM. Differences were assessed by the Mann–Whitney U test. Significance was established at adjusted P < 0.05 with a false discovery rate (FDR) of 0.05

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