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Fig. 5 | BMC Biology

Fig. 5

From: Indoleacrylic acid produced by Parabacteroides distasonis alleviates type 2 diabetes via activation of AhR to repair intestinal barrier

Fig. 5

P. distasonis inactivates NF-κb signaling via inhibition of TLR4 signaling. A Relative mRNA expression of TLR4, Myd88, and NF-κB in colon tissue of rats (n = 8 per group). Each dot shows the value from each independent replicate. B Representative Western blot and densitometric analyses of TLR4, Myd88, NF-κB pP65, and NF-κB P65 protein in colon tissue of rats (n = 6 per group). Each dot shows the value from each independent replicate. C The ratio of NF-κB pP65 to NF-κB p65 among all groups (n = 6 per group). Data are expressed as mean ± SEM. Differences were assessed by the Mann–Whitney U test. Significance was established at adjusted P < 0.05 with a false discovery rate (FDR) of 0.05

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