Table 2 List of putative cancer-related candidate genes found to be selected (Ka/Ks > 1) in all three pairwise comparisons of large- and small-bodied baleen whales. Genes were identified based on the imbalance between nonsynonymous (Ka) and synonymous (Ks) substitution rates. Pairs were determined using phylogenetic targeting. Sorted by Ka/Ks ratio. Concerning publications: [66,67,68,69,70]
From: The genome of the pygmy right whale illuminates the evolution of rorquals
Symbol | HGNC | Orthogroup | Description | Literature | Ka/Ks | p-val |
|---|---|---|---|---|---|---|
LOC124907494/LOC124905498 | - | OG0018750 | Uncharacterized (basic salivary proline-rich protein 1-like in Bos indicus) | - | 8.19 | 0.001 |
C6orf15 (STG) | 13,927 | OG0018717 | Unknown function (expressed in various types of cancer) | Xiong et al., (2022) [66] | 2.74 | 0.165 |
MGAT4EP | 49,418 | OG0018311 | Pseudogene in human (upregulates the expression of FOXM1 in breast cancer) | Sun et al., (2021) [67] | 2.06 | 0.474 |
CLEC2B/AICL | 2053 | OG0018915 | Associated with natural killer cells, expressed in various types of cancer | Li et al., (2022) [68] | 1.95 | 0.532 |
REP15 | 33,748 | OG0018380 | Involved in vesicular trafficking, potentially involved in various types of cancer | Rai et al., (2022) [69] | 1.67 | 0.403 |
C22orf46 | 26,294 | OG0017847 | Unknown function (oncogene in adreno-cortical carcinoma) | Li et al., (2020) [70] | 1.43 | 0.435 |