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Fig. 6 | BMC Biology

Fig. 6

From: CLARITY increases sensitivity and specificity of fluorescence immunostaining in long-term archived human brain tissue

Fig. 6

Cyto- and myeloarchitectonics in the human cerebral cortex after CLARITY. a (left) Cytoarchitectonics by 3D CAMKIIA imaging (MIP of stack with z = 25.5 µm) in the frontal cortex (perfusion-fixed) opposed to a schematic drawing based on Henry Gray. The inset (scale bar, 20 µm) shows the dendritic tufts of layer I. (right) Myeloarchitectonics as revealed by 2D MBP staining in the frontal cortex (case p1) opposed to a schematic drawing showing a non-immuno-based myelin stain found in anatomy textbooks. The inset (scale bar, 10 µm) shows the horizontal and transverse arrangement of fibers. Scale bars, 200 µm. b MAP2 immunostaining in the superior frontal gyrus of case p1, MIP of stack with z = 25.5 µm. Scale bar, 200 µm

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