CLARITY increases sensitivity and specificity of fluorescence immunostaining in long-term archived human brain tissue

Table 1 Demographics and clinical-neuropathological diagnoses of the n = 6 cases studied

Case	Age (yrs)	Sex	NFT stage	Aβ phase	PD stage	PMI (h)	Fixation year	Origin		Cause of death
								Anatomy course	Tissue bank
p1	71	M	I	0	0	72	2019	x		Cardiogenic shock
p2	74	M	I	3	0	24	2017	x		Decompensated heart insufficiency
i1	49	F	0	0	0	N.a.	2016		x	N.a.
i2	82	F	II	1	0	71	2015		x	Stroke
i3	80	M	III	0	0	39	2003		x	Malignant neoplasm
i4	78	M	I	0	0	56	2003		x	COPD

Abbreviations: yrs Years, NFT Neurofibrillary tangle, Aβ Amyloid-β, PD Parkinson’s disease, PMI Post mortem interval, h Hour, p Perfusion fixation, i Immersion fixation, F Female, M Male, N.a. Not available, COPD Chronic obstructive pulmonary disease

ISSN: 1741-7007