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Fig. 2 | BMC Biology

Fig. 2

From: Promoter evolution of mammalian gene duplicates

Fig. 2

Sequence similarity between promoters of paralogs in segmental versus retrotransposition-mediated duplications. A Sequence similarity score between promoter regions of human paralogs, where paralogs are partitioned based on their inferred duplication time (as in Fig. 1) and based on inferred duplication mechanism: retrotransposition or segmental duplication, in red and blue, respectively. In each group of paralogs belonging to the same TMRCA, the distribution of similarity scores is compared between retrotransposition-mediated and segmental duplications. Comparison between the distributions was preformed using a Mann–Whitney one-sided test and corrected by FDR. (NA—only segmental duplications exist in this group). B As in A, but with mouse paralogs. C As in A, but with partitioning of paralogs based on their dS values (synonymous substitution rate between paralogs). Paralogs are binned into equal-sized bins. Left-most bins represent the highest dS values, and likely the oldest duplicates, while right-most bins represent lowest dS values. D as in C, only with mouse paralogs. (***P < 0.001, **P < 0.01, *P < 0.05). Group size numbers appear in Additional File 2: Table 2

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