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Fig. 4 | BMC Biology

Fig. 4

From: TRPM4 regulates hilar mossy cell loss in temporal lobe epilepsy

Fig. 4

Increased seizure susceptibility in KA injected WT mice compared to Trpm4/. A Timeline of the experiments. Mice underwent KA or saline (ctrl) injection. Ten days later EEG electrodes were implanted. Fourteen days later, mice underwent spontaneous IED detection; 21 days later seizures were induced with i.p. KA injection and detected with videoEEG. B Representative EEG recordings (lower panel) and corresponding spectrograms (upper panel) 14 days after KA injection in WT (black) and Trpm4/ (red) mice. Triangles indicate individual IED events. C Representative EEG recordings (lower panel) and corresponding spectrograms (upper panel) 21 days after KA injection in WT (black) and Trpm4/ (red) mice after KA injection. Triangles indicate seizures. D Statistics showing the number of spontaneous IED/h 14 days after IHKA. n = 8 for WT and 7 for Trpm4/. Statistics showing the E number of seizures, F seizure duration, and G spike amplitude in 2 h after i.p. KA injection. n = 10 for WT and 10 for Trpm4/. Data are presented as mean ± SD. *p < 0.05

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