Fig. 5

Schematic representation of the expected levels of LOH acquisition through a mitotic recombination or b stress-induced DNA breaks or meiotic recombination. The color grade scale indicates the color variation between low levels of LOH (light blue) and high levels of LOH (dark blue). The dashed line marks the common ancestor of strains of the same clade, after which different strains of a clade start diverging. In a scenario where only mitotic recombination takes place, the acquisition of LOH blocks is expected to proceed slowly and be proportional to time. In addition, SNPs and LOH levels are expected to increase in parallel as both processes would linearly accumulate with time. In a scenario of stress-induced DNA breaks or meiotic recombination, multiple LOH events are created in a single event, and strains progress much faster to high levels of LOH, as compared to mitotic recombination. In addition, LOH and SNP accumulation are uncoupled, and thus, levels of LOH and SNPs are not expected to correlate