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Table 1 The common detoxification and metabolic genes differentially upregulated in Sahel An. coluzzii (log2FC values and FDR-adjusted p < 0.05)

From: Molecular drivers of insecticide resistance in the Sahelo-Sudanian populations of a major malaria vector Anopheles coluzzii

 

NIGERIA

NIGER

CHAD

CAMEROON

 

Gene

R-S

C-S

R-S

C-S

R-S

C-S

R-S

C-S

Gene description

AGAP006400

2.2

4.2

1.7

4.5

-

-

2.1

2.8

Alkaline phosphatase 2

AGAP028491

4.3

2.8

1.4

2.7

2.9

2.6

-

-

Aquaporin, AQP2

AGAP010326

14.8

11.0

12.1

21.9

14.9

1.2

14.2

17.3

Aquaporin, AQP3

AGAP005372

9.5

12.2

3.3

4.3

6.6

3.6

1.4

2.6

Carboxylesterase, COEBE3C

AGAP005837

4.7

5.0

1.4

3.3

1.9

2.6

  

Carboxylesterase, COEJHE5E

AGAP004904

3.9

2.2

-

-

2.3

1.7

-

-

Catalase, CAT1

AGAP029127

4.1

3.2

-

-

1.7

2.2

-

-

Chemosensory protein 5, CSP5

AGAP006191

21.1

38.6

40.1

67.2

91.4

5.7

44.3

40.5

Chitinase, Cht24

AGAP013260

4.4

11.5

1.3

3.9

3.1

0.8

-

-

Chitinase, Cht5-5

AGAP006898

8.9

5.5

-

-

2.2

3.9

-

-

Chitinase, Cht6

AGAP006709

31.6

54.4

12.3

41.6

18.0

18.1

5.7

11.8

Chymotrypsin-1, CHYM1

AGAP006710

9.9

19.4

2.1

8.8

4.2

3.9

-

-

Chymotrypsin-2, CHYM2

AGAP006711

32.5

58.4

7.3

43.3

13.4

7.2

2.6

8.2

Chymotrypsin-3, CHYM3

AGAP000987

4.3

2.7

-

-

1.3

2.6

-

-

Cuticular protein, CPAP3-A1b

AGAP000988

5.3

1.6

-

-

0.7

5.4

-

-

Cuticular protein, CPAP3-A1c

AGAP000986

7.3

4.6

-

-

1.7

3.5

-

-

Cuticular protein, CPAP3-D

AGAP006149

3.8

0.8

-

-

0.7

5.8

-

-

Cuticular protein, CPLCX3

AGAP010123

33.3

54.9

2.4

13.2

-

-

-

-

Cuticular protein, CPR131

AGAP005456

5.2

1.8

-

-

1.2

2.2

1.1

2.1

Cuticular protein, CPR15

AGAP006009

-

-

2.9

1.3

-

-

3.9

1.6

Cuticular protein, CPR30

AGAP009871

8.7

2.7

1.1

2.6

2.2

4.2

1.7

2.6

Cuticular protein, CPR75

AGAP009874

10.6

2.2

1.1

2.6

3.7

5.6

1.1

2.0

Cuticular protein, CPR76

AGAP009879

7.4

2.6

-

-

1.9

4.6

-

-

Cuticular protein, CPR81

AGAP006422

7.5

9.4

-

-

8.4

7.3

2.1

2.0

Cyanogenic-beta-glucosidase

AGAP002417

5.5

4.2

0.9

1.2

1.9

1.9

-

-

Cytochrome P450, CYP4AR1

AGAP009246

7.4

4.6

4.0

5.6

6.0

2.6

2.0

2.6

Cytochrome P450, CYP4C27

AGAP012957

5.0

2.8

-

-

2.9

2.5

2.0

2.6

Cytochrome P450, CYP4D17

AGAP001076

5.8

4.7

1.5

1.8

3.8

2.4

0.9

1.5

Cytochrome P450, CYP4G16

AGAP000877

3.8

2.0

2.3

1.9

3.8

2.1

1.2

2.1

Cytochrome P450, CYP4G17

AGAP008358

-

-

2.9

4.1

3.4

3.3

3.6

2.0

Cytochrome P450, CYP4H17

AGAP007480

5.4

3.9

1.3

2.7

2.5

2.0

-

-

Cytochrome P450, CYP6AH1

AGAP002865

1.11

0.5

2.3

1.9

0.7

12.8

2.1

2.3

Cytochrome P450, CYP6P3

AGAP008207

3.6

1.9

-

-

2.1

1.6

1.7

2.4

Cytochrome P450, CYP6Y2

AGAP008218

6.6

2.1

6.7

2.3

14.0

1.5

11.8

8.4

Cytochrome P450, CYP6Z2

AGAP008217

4.7

1.8

6.1

1.4

3.5

1.1

7.1

3.8

Cytochrome P450, CYP6Z3

AGAP000818

3.0

1.2

0.8

0.5

0.9

1.6

3.4

2.2

Cytochrome P450, CYP9K1

AGAP010400

3.6

2.6

1.6

2.8

3.3

1.4

-

-

Flavin-containing monooxygenase

AGAP007920

5.7

2.4

2.8

1.8

-

-

-

-

Glucuronosyltransferases, UGT-B19

AGAP004164

2.2

1.9

1.7

2.3

1.4

1.3

-

-

Glutathione S-transferase, GSTD1-4

AGAP009194

9.6

7.2

6.6

11.3

9.1

10.0

9.7

20.7

Glutathione S-transferase, GSTe2

AGAP009193

3.3

2.3

1.1

2.1

1.5

1.6

-

-

Glutathione S-transferase, GSTe4

AGAP000947

4.4

2.3

1.2

2.2

1.9

3.2

-

-

Glutathione S-transferase, GSTU1

AGAP002898

5.5

3.5

1.7

2.6

2.8

2.4

-

-

Glutathione S-transferase, GSTZ1

AGAP002198

-

-

2.0

5.8

4.8

6.6

-

-

Glycine-N-methyltransferase

AGAP013327

-

-

1.2

7.3

7.9

20.1

5.1

14.8

Heme peroxidase, HXP15

AGAP002353

26.7

20.8

16.5

29.8

15.0

10

14.6

14.5

Lipase

AGAP000184

5.2

6.3

-

-

4.9

4.3

1.2

1.9

Malate dehydrogenase

AGAP008051

3.7

4.0

1.1

1.3

1.7

1.7

-

-

Sensory appendage protein 1, SAP1

AGAP008052

5.5

10.8

1.0

1.5

3.6

1.1

-

-

Sensory appendage protein 2, SAP2

AGAP010815

5.7

14.4

4.1

8.6

7.8

3.8

1.7

3.1

Thioester-containing protein, TEP1

AGAP008368

3.3

6.1

1.4

3.9

3.4

2.0

-

-

Thioester-containing protein, TEP14

AGAP008654

4.6

17.4

2.1

10.0

-

-

-

-

Thioester-containing protein, TEP12

AGAP008227

4.1

4.0

4.0

2.0

4.6

1.5

2.6

4.1

Trehalose 6-phosphate synthase/phosphatase

AGAP012818

22.1

14.6

31.1

25.4

6.0

4.3

44.9

43.4

V-type proton ATPase, subunit a