Fig. 1

Epigenome profiling in the PFC cortex. A, B Graphical representation of the global peak distribution. hcm: Peaks shared among all three primates; cm, hc, hm: Peaks shared between pairwise primates; c, h, m: Peaks unique to each primate. The number of peaks is shown on the y-axis (n = 3) (See replicate data in Additional file 1: Tables S3 and S4). C, D Overlap of peaks within each individual and given features based on genomic coordinates. Different colors denote different genomic features. The x-axis denotes the proportion of peaks intersected with specific genomic features. The y-axis denotes each primate (n = 3) (See replicate data in Additional file 1: Tables S3 and S4). E, F Hierarchical clustering of three humans, three chimpanzees, and three macaques based on either correlation of peak intensity (top left) or overlap of peak coordinates (bottom right) for H3K4me3 (E) and H3K27ac (F) epigenome (n = 3) (See replicate data in Additional file 1: Tables S3 and S4). G, H Principal components based on the peak intensity of H3K4me3 (G) and H3K27ac (H). Each point represents an individual; colors represent primates (red, human; blue, chimpanzee; green, macaque). The proportion of variance explained by each component is shown on the axis labels (n = 3) (See replicate data in Additional file 1: Tables S3 and S4)