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Fig. 5 | BMC Biology

Fig. 5

From: Circular RNAs arising from synaptic host genes during human neuronal differentiation are modulated by SFPQ RNA-binding protein

Fig. 5

Long introns flank circRNAs increased by NES differentiation. a Frequency of SFPQ motifs in circRNA flanking introns by distance relative to intron splice site distal from the BSJ. b Frequency of SFPQ motifs in circRNA flanking introns by distance relative to the 5′ intron end. Scale in b applies to a and b. c Proportion of flanking intron types among all circRNAs compared to increased circRNAs. Intron types were defined as either, short/long introns with a proximal IAE (pIAE-short/pIAE-long) or short/long introns without proximal IAE (Short/Long). d Mean intron length of flanking introns. e Mean distance to IAE from BSJ. f Density plot of intron length totalled from both flanking introns. g Density plot of IAE distance totalled from Alu element distance on both flanking introns. Error bars in d and e represent standard error; dashed lines in g and f indicate median values. Two-sample Z-test, ****p < 0.0001

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