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  1. After a volcano erupts, a lake may form in the cooled crater and become an isolated aquatic ecosystem. This makes fishes in crater lakes informative for understanding sympatric evolution and ecological diversi...

    Authors: Kathryn R Elmer, Topi K Lehtonen, Andreas F Kautt, Chris Harrod and Axel Meyer

    Citation: BMC Biology 2010 8:60

    Content type: Research article

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    The Erratum to this article has been published in BMC Biology 2012 10:70

  2. Ultra-high throughput sequencing technologies provide opportunities both for discovery of novel molecular species and for detailed comparisons of gene expression patterns. Small RNA populations are particularl...

    Authors: Daniela Witten, Robert Tibshirani, Sam Guoping Gu, Andrew Fire and Weng-Onn Lui

    Citation: BMC Biology 2010 8:58

    Content type: Research article

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  3. Small interfering RNAs can trigger unintended, microRNA-like off-target effects, but the impact of these effects on functional studies has been controversial. A recent study in BMC Genomics shows that microRNA-li...

    Authors: Peter S Linsley and Aimee L Jackson

    Citation: BMC Biology 2010 8:53

    Content type: Commentary

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  4. The interfacial molecular mechanisms that regulate mammalian cell growth and differentiation have important implications for biotechnology (production of cells and cell products) and medicine (tissue engineeri...

    Authors: Elizabeth A Mitchell, Benjamin T Chaffey, Andrew W McCaskie, Jeremy H Lakey and Mark A Birch

    Citation: BMC Biology 2010 8:57

    Content type: Methodology article

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  5. Transcription is the first step of gene expression and is characterized by a high fidelity of RNA synthesis. During transcription, the RNA polymerase active centre discriminates against not just non-complement...

    Authors: Yulia Yuzenkova, Aleksandra Bochkareva, Vasisht R Tadigotla, Mohammad Roghanian, Savva Zorov, Konstantin Severinov and Nikolay Zenkin

    Citation: BMC Biology 2010 8:54

    Content type: Research article

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  6. Next-generation sequencing can be used to compare transcriptomes under different conditions. A study in BMC Genomics applies this approach to investigating the effects of exposure to a range of xenobiotics on cha...

    Authors: John Vontas, Hilary Ranson and Luke Alphey

    Citation: BMC Biology 2010 8:52

    Content type: Commentary

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  7. The phylogenetic systematics of bovin species forms a common basis for studies at multiple scales, from the level of domestication in populations to major cladogenesis. The main big-picture accomplishments of ...

    Authors: Faysal Bibi and Elisabeth S Vrba

    Citation: BMC Biology 2010 8:50

    Content type: Commentary

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  8. Molecular interaction networks provide a window on the workings of the cell. However, combining various types of networks into one coherent large-scale dynamic model remains a formidable challenge. A recent pa...

    Authors: Teresa M Przytycka and Yoo-Ah Kim

    Citation: BMC Biology 2010 8:48

    Content type: Commentary

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  9. In mammalian cells, the integrity of the primary cilium is critical for proper regulation of the Hedgehog (Hh) signal transduction pathway. Whether or not this dependence on the primary cilium is a universal f...

    Authors: Hyejeong Rosemary Kim, Joanna Richardson, Freek van Eeden and Philip W Ingham

    Citation: BMC Biology 2010 8:65

    Content type: Research article

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  10. A culture's icons are a window onto its soul. Few would disagree that, in the culture of molecular biology that dominated much of the life sciences for the last third of the 20th century, the dominant icon was...

    Authors: Arthur D Lander

    Citation: BMC Biology 2010 8:40

    Content type: Opinion

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  11. Most of the significant recent advances in cancer treatment have been based on the great strides that have been made in our understanding of the underlying biology of the disease. Nevertheless, the exploitatio...

    Authors: Christopher J Lord and Alan Ashworth

    Citation: BMC Biology 2010 8:38

    Content type: Review

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  12. The various tasks of visual systems, including course control, collision avoidance and the detection of small objects, require at the neuronal level the dendritic integration and subsequent processing of many ...

    Authors: Christian Spalthoff, Martin Egelhaaf, Philip Tinnefeld and Rafael Kurtz

    Citation: BMC Biology 2010 8:36

    Content type: Research article

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  13. One of the four principal categories of cell-cell junctions that hold together and shape distinct tissues and organs in vertebrates, adherens junctions (AJs) form cell-cell contacts that connect transmembrane ...

    Authors: Matthias M Falk

    Citation: BMC Biology 2010 8:34

    Content type: Commentary

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  14. Neoplastic overgrowth depends on the cooperation of several mutations ultimately leading to major rearrangements in cellular behaviour. Precancerous cells are often removed by cell death from normal tissues in...

    Authors: Francesca Froldi, Marcello Ziosi, Flavio Garoia, Andrea Pession, Nicola A Grzeschik, Paola Bellosta, Dennis Strand, Helena E Richardson, Annalisa Pession and Daniela Grifoni

    Citation: BMC Biology 2010 8:33

    Content type: Research article

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  15. Tiny marine animals that complete their life cycle in the total absence of light and oxygen are reported by Roberto Danovaro and colleagues in this issue of BMC Biology. These fascinating animals are new members ...

    Authors: Marek Mentel and William Martin

    Citation: BMC Biology 2010 8:32

    Content type: Commentary

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  16. The sediments of a deep-sea hypersaline and sulfidic Mediterranean basin have yielded an unexpected discovery, the first multicellular animals living entirely without oxygen. Reported by Danovaro et al. in BMC Bi...

    Authors: Lisa A Levin

    Citation: BMC Biology 2010 8:31

    Content type: Commentary

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  17. Several unicellular organisms (prokaryotes and protozoa) can live under permanently anoxic conditions. Although a few metazoans can survive temporarily in the absence of oxygen, it is believed that multi-cellu...

    Authors: Roberto Danovaro, Antonio Dell'Anno, Antonio Pusceddu, Cristina Gambi, Iben Heiner and Reinhardt Møbjerg Kristensen

    Citation: BMC Biology 2010 8:30

    Content type: Research article

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  18. Due to its high polymorphism and importance for disease resistance, the major histocompatibility complex (MHC) has been an important focus of many vertebrate genome projects. Avian MHC organization is of parti...

    Authors: Christopher N Balakrishnan, Robert Ekblom, Martin Völker, Helena Westerdahl, Ricardo Godinez, Holly Kotkiewicz, David W Burt, Tina Graves, Darren K Griffin, Wesley C Warren and Scott V Edwards

    Citation: BMC Biology 2010 8:29

    Content type: Research article

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  19. Among songbirds, the zebra finch (Taeniopygia guttata) is an excellent model system for investigating the neural mechanisms underlying complex behaviours such as vocal communication, learning and social interacti...

    Authors: Fang Xie, Sarah E London, Bruce R Southey, Suresh P Annangudi, Andinet Amare, Sandra L Rodriguez-Zas, David F Clayton and Jonathan V Sweedler

    Citation: BMC Biology 2010 8:28

    Content type: Research article

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  20. Self-complementary RNA transcripts form a double-stranded RNA (dsRNA) that triggers a sequence-specific mRNA degradation, in a process known as RNA interference (RNAi), leading to gene silencing. In vascular p...

    Authors: Maria Laine P Tinoco, Bárbara BA Dias, Rebeca C Dall'Astta, João A Pamphile and Francisco JL Aragão

    Citation: BMC Biology 2010 8:27

    Content type: Research article

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  21. Speculation regarding the importance of changes in gene regulation in determining major phylogenetic patterns continues to accrue, despite a lack of broad-scale comparative studies examining how patterns of ge...

    Authors: Carlo G Artieri and Rama S Singh

    Citation: BMC Biology 2010 8:26

    Content type: Research article

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  22. Microbial denitrification is not considered important in human-associated microbial communities. Accordingly, metabolic investigations of the microbial biofilm communities of human dental plaque have focused o...

    Authors: Frank Schreiber, Peter Stief, Armin Gieseke, Ines M Heisterkamp, Willy Verstraete, Dirk de Beer and Paul Stoodley

    Citation: BMC Biology 2010 8:24

    Content type: Research article

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  23. The ankyrin repeat and suppressor of cytokine signalling (SOCS) box proteins (Asbs) are a large protein family implicated in diverse biological processes including regulation of proliferation and differentiati...

    Authors: Sanghoon Kwon, Dongbum Kim, Jae Won Rhee, Jeong-A Park, Dae-Won Kim, Doo-Sik Kim, Younghee Lee and Hyung-Joo Kwon

    Citation: BMC Biology 2010 8:23

    Content type: Research article

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  24. Large-scale intervention programmes to control or eliminate several infectious diseases are currently underway worldwide. However, a major unresolved question remains: what are reasonable stopping points for t...

    Authors: Manoj Gambhir, Moses Bockarie, Daniel Tisch, James Kazura, Justin Remais, Robert Spear and Edwin Michael

    Citation: BMC Biology 2010 8:22

    Content type: Research article

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  25. The increased battery of molecular markers, derived from comparative genomics, is aiding our understanding of the genetics of domestication. The recent BMC Biology article pertaining to the evolution of small siz...

    Authors: Rodney L Honeycutt

    Citation: BMC Biology 2010 8:20

    Content type: Commentary

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  26. Among the greatest challenges for biology in the 21st century is inference of the tree of life. Interest in, and progress toward, this goal has increased dramatically with the growing availability of molecular...

    Authors: Robert C Thomson and H Bradley Shaffer

    Citation: BMC Biology 2010 8:19

    Content type: Correspondence

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  27. Technological advances have enabled the accurate quantification of gene expression, even within single cell types. While transcriptome analyses are routinely performed, most experimental designs only provide s...

    Authors: Rémy Merret, Bruno Moulia, Irène Hummel, David Cohen, Erwin Dreyer and Marie-Béatrice Bogeat-Triboulot

    Citation: BMC Biology 2010 8:18

    Content type: Methodology article

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  28. The Dlc1 (deleted in liver cancer 1) tumour suppressor gene codes for a RhoGTPase activating protein that is found inactivated in many tumour types. Several transcriptional isoforms have been described but the...

    Authors: Mohammad G Sabbir, Nichola Wigle, Shauna Loewen, Yuan Gu, Cordula Buse, Geoffrey G Hicks and Michael RA Mowat

    Citation: BMC Biology 2010 8:17

    Content type: Research article

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  29. A selective sweep containing the insulin-like growth factor 1 (IGF1) gene is associated with size variation in domestic dogs. Intron 2 of IGF1 contains a SINE element and single nucleotide polymorphism (SNP) foun...

    Authors: Melissa M Gray, Nathan B Sutter, Elaine A Ostrander and Robert K Wayne

    Citation: BMC Biology 2010 8:16

    Content type: Research article

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  30. The Tarim Basin, located on the ancient Silk Road, played a very important role in the history of human migration and cultural communications between the West and the East. However, both the exact period at wh...

    Authors: Chunxiang Li, Hongjie Li, Yinqiu Cui, Chengzhi Xie, Dawei Cai, Wenying Li, Victor H Mair, Zhi Xu, Quanchao Zhang, Idelisi Abuduresule, Li Jin, Hong Zhu and Hui Zhou

    Citation: BMC Biology 2010 8:15

    Content type: Research article

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  31. Many Caenorhabditis elegans mutations increase longevity and much evidence suggests that they do so at least partly via changes in metabolism. However, up until now there has been no systematic investigation of h...

    Authors: Silke Fuchs, Jacob G Bundy, Sarah K Davies, Jonathan M Viney, Jonathan S Swire and Armand M Leroi

    Citation: BMC Biology 2010 8:14

    Content type: Research article

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  32. Lignification of the fruit endocarp layer occurs in many angiosperms and plays a critical role in seed protection and dispersal. This process has been extensively studied with relationship to pod shatter or de...

    Authors: Christopher D Dardick, Ann M Callahan, Remo Chiozzotto, Robert J Schaffer, M Claudia Piagnani and Ralph Scorza

    Citation: BMC Biology 2010 8:13

    Content type: Research article

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