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  1. Content type: Research article

    The bacterial ribosome is a primary target of several classes of antibiotics. Investigation of the structure of the ribosomal subunits in complex with different antibiotics can reveal the mode of inhibition of...

    Authors: Jörg M Harms, Frank Schlünzen, Paola Fucini, Heike Bartels and Ada Yonath

    Citation: BMC Biology 2004 2:4

    Published on:

  2. Content type: Research article

    Phylogenetic analyses of jawed vertebrates based on mitochondrial sequences often result in confusing inferences which are obviously inconsistent with generally accepted trees. In particular, in a hypothesis b...

    Authors: Kanae Kikugawa, Kazutaka Katoh, Shigehiro Kuraku, Hiroshi Sakurai, Osamu Ishida, Naoyuki Iwabe and Takashi Miyata

    Citation: BMC Biology 2004 2:3

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  3. Content type: Research article

    Glutaminyl cyclase (QC) forms the pyroglutamyl residue at the amino terminus of numerous secretory peptides and proteins. We previously proposed the mammalian QC has some features in common with zinc aminopept...

    Authors: Rachell E Booth, Simon C Lovell, Stephanie A Misquitta and Robert C Bateman Jr

    Citation: BMC Biology 2004 2:2

    Published on:

  4. Content type: Research article

    The earliest fossil evidence of terrestrial animal activity is from the Ordovician, ~450 million years ago (Ma). However, there are earlier animal fossils, and most molecular clocks suggest a deep origin of an...

    Authors: Davide Pisani, Laura L Poling, Maureen Lyons-Weiler and S Blair Hedges

    Citation: BMC Biology 2004 2:1

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  5. Content type: Research article

    RNA silencing processes are widespread in almost all eukaryotic organisms. They have various functions including genome protection, and the control of gene expression, development and heterochromatin formation...

    Authors: Mickaël Durand-Dubief and Philippe Bastin

    Citation: BMC Biology 2003 1:2

    Published on:

  6. Content type: Research article

    The assessment of data reproducibility is essential for application of microarray technology to exploration of biological pathways and disease states. Technical variability in data analysis largely depends on ...

    Authors: Vikram Budhraja, Edward Spitznagel, W Timothy Schaiff and Yoel Sadovsky

    Citation: BMC Biology 2003 1:1

    Published on:

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