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  1. The heat shock protein Hsp70 promotes inducible thermotolerance in nearly every organism examined to date. Hsp70 interacts with a network of other stress-response proteins, and dissecting the relative roles of...

    Authors: Brian R Bettencourt, Catherine C Hogan, Mario Nimali and Brian W Drohan

    Citation: BMC Biology 2008 6:5

    Content type: Research article

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  2. To study the organization and interaction with the fusion domain (or fusion peptide, FP) of the transmembrane domain (TMD) of influenza virus envelope glycoprotein for its role in membrane fusion which is also...

    Authors: Ding-Kwo Chang, Shu-Fang Cheng, Eric Aseen B Kantchev, Chi-Hui Lin and Yu-Tsan Liu

    Citation: BMC Biology 2008 6:2

    Content type: Research article

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  3. O-fucosyltransferase1 (OFUT1) is a conserved ER protein essential for Notch signaling. OFUT1 glycosylates EGF domains, which can then be further modified by the N-acetylglucosaminyltransferase Fringe. OFUT1 also...

    Authors: Tetsuya Okajima, BVVG Reddy, Tsukasa Matsuda and Kenneth D Irvine

    Citation: BMC Biology 2008 6:1

    Content type: Research article

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  4. A central question in the evolutionary diversification of large, widespread, mobile mammals is how substantial differentiation can arise, particularly in the absence of topographic or habitat barriers to dispe...

    Authors: David M Brown, Rick A Brenneman, Klaus-Peter Koepfli, John P Pollinger, Borja Milá, Nicholas J Georgiadis, Edward E Louis Jr, Gregory F Grether, David K Jacobs and Robert K Wayne

    Citation: BMC Biology 2007 5:57

    Content type: Research article

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  5. Insects helped pioneer, and persist as model organisms for, the study of specific aspects of immunity. Although they lack an adaptive immune system, insects possess an innate immune system that recognizes and ...

    Authors: Dalial Freitak, Christopher W Wheat, David G Heckel and Heiko Vogel

    Citation: BMC Biology 2007 5:56

    Content type: Research article

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  6. The genus Cuscuta L. (Convolvulaceae), commonly known as dodders, are epiphytic vines that invade the stems of their host with haustorial feeding structures at the points of contact. Although they lack expanded l...

    Authors: Joel R McNeal, Kathiravetpilla Arumugunathan, Jennifer V Kuehl, Jeffrey L Boore and Claude W dePamphilis

    Citation: BMC Biology 2007 5:55

    Content type: Research article

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  7. The urine of freshwater fish species investigated so far acts as a vehicle for reproductive pheromones affecting the behaviour and physiology of the opposite sex. However, the role of urinary pheromones in int...

    Authors: Eduardo N Barata, Peter C Hubbard, Olinda G Almeida, António Miranda and Adelino VM Canário

    Citation: BMC Biology 2007 5:54

    Content type: Research article

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  8. Cell shape changes during cytokinesis and chemotaxis require regulation of the actin cytoskeletal network. Dynacortin, an actin cross-linking protein, localizes to the cell cortex and contributes to cortical r...

    Authors: Cathryn Kabacoff, Yuan Xiong, Runa Musib, Elizabeth M Reichl, John Kim, Pablo A Iglesias and Douglas N Robinson

    Citation: BMC Biology 2007 5:53

    Content type: Research article

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  9. In daily life, we are exposed to different sound inputs simultaneously. During neural encoding in the auditory pathway, neural activities elicited by these different sounds interact with each other. In the pre...

    Authors: Hidehiko Okamoto, Henning Stracke, Bernhard Ross, Ryusuke Kakigi and Christo Pantev

    Citation: BMC Biology 2007 5:52

    Content type: Research article

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  10. The exceptionally diverse species flocks of cichlid fishes in East Africa are prime examples of parallel adaptive radiations. About 80% of East Africa's more than 1 800 endemic cichlid species, and all species...

    Authors: Walter Salzburger, Ingo Braasch and Axel Meyer

    Citation: BMC Biology 2007 5:51

    Content type: Research article

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  11. Carpenter ants (genus Camponotus) are considered to be omnivores. Nonetheless, the genome sequence of Blochmannia floridanus, the obligate intracellular endosymbiont of Camponotus floridanus, suggests a function ...

    Authors: Heike Feldhaar, Josef Straka, Markus Krischke, Kristina Berthold, Sascha Stoll, Martin J Mueller and Roy Gross

    Citation: BMC Biology 2007 5:48

    Content type: Research article

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  12. The homeobox genes are a large and diverse group of genes, many of which play important roles in the embryonic development of animals. Increasingly, homeobox genes are being compared between genomes in an atte...

    Authors: Peter WH Holland, H Anne F Booth and Elspeth A Bruford

    Citation: BMC Biology 2007 5:47

    Content type: Research article

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  13. Direct visualization of data sets in the context of biochemical network drawings is one of the most appealing approaches in the field of data evaluation within systems biology. One important type of informatio...

    Authors: Stephan Noack, Aljoscha Wahl, Ermir Qeli and Wolfgang Wiechert

    Citation: BMC Biology 2007 5:46

    Content type: Research article

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  14. Molecular interaction Information is a key resource in modern biomedical research. Publicly available data have previously been provided in a broad array of diverse formats, making access to this very difficul...

    Authors: Samuel Kerrien, Sandra Orchard, Luisa Montecchi-Palazzi, Bruno Aranda, Antony F Quinn, Nisha Vinod, Gary D Bader, Ioannis Xenarios, Jérôme Wojcik, David Sherman, Mike Tyers, John J Salama, Susan Moore, Arnaud Ceol, Andrew Chatr-aryamontri, Matthias Oesterheld…

    Citation: BMC Biology 2007 5:44

    Content type: Software

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  15. Shaker codes for a Drosophila voltage-dependent potassium channel. Flies carrying Shaker null or hypomorphic mutations sleep 3–4 h/day instead of 8–14 h/day as their wild-type siblings do. Shaker-like channels a...

    Authors: Christopher L Douglas, Vladyslav Vyazovskiy, Teresa Southard, Shing-Yan Chiu, Albee Messing, Giulio Tononi and Chiara Cirelli

    Citation: BMC Biology 2007 5:42

    Content type: Research article

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  16. Dinoflagellates comprise an ecologically significant and diverse eukaryotic phylum that is sister to the phylum containing apicomplexan endoparasites. The mitochondrial genome of apicomplexans is uniquely redu...

    Authors: Christopher J Jackson, John E Norman, Murray N Schnare, Michael W Gray, Patrick J Keeling and Ross F Waller

    Citation: BMC Biology 2007 5:41

    Content type: Research article

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  17. The contrasting dose of sex chromosomes in males and females potentially introduces a large-scale imbalance in levels of gene expression between sexes, and between sex chromosomes and autosomes. In many organi...

    Authors: Hans Ellegren, Lina Hultin-Rosenberg, Björn Brunström, Lennart Dencker, Kim Kultima and Birger Scholz

    Citation: BMC Biology 2007 5:40

    Content type: Research article

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  18. Wolbachia are obligate endosymbiotic bacteria maternally transmitted through the egg cytoplasm that are responsible for several reproductive disorders in their insect hosts, such as cytoplasmic incompatibility (...

    Authors: Thomas Walker, Lisa Klasson, Mohammed Sebaihia, Mandy J Sanders, Nicholas R Thomson, Julian Parkhill and Steven P Sinkins

    Citation: BMC Biology 2007 5:39

    Content type: Research article

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  19. Histone modifications have been implicated in the regulation of transcription and, more recently, in DNA replication and repair. In yeast, a major conserved histone acetyltransferase, Hat1p, preferentially ace...

    Authors: Bernhard Suter, Oxana Pogoutse, Xinghua Guo, Nevan Krogan, Peter Lewis, Jack F Greenblatt, Jasper Rine and Andrew Emili

    Citation: BMC Biology 2007 5:38

    Content type: Research article

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  20. The parvulin-type peptidyl prolyl cis/trans isomerase Par14 is highly conserved in all metazoans. The recently identified parvulin Par17 contains an additional N-terminal domain whose occurrence and function was ...

    Authors: Daniel Kessler, Panagiotis Papatheodorou, Tina Stratmann, Elke Andrea Dian, Cristina Hartmann-Fatu, Joachim Rassow, Peter Bayer and Jonathan Wolf Mueller

    Citation: BMC Biology 2007 5:37

    Content type: Research article

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  21. In mouse the cytokine interleukin-7 (IL-7) is required for generation of B lymphocytes, but human IL-7 does not appear to have this function. A bioinformatics approach was therefore used to identify IL-7 recep...

    Authors: Delicia L Munfus, Christopher L Haga, Peter D Burrows and Max D Cooper

    Citation: BMC Biology 2007 5:36

    Content type: Research article

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  22. Various typing methods have been developed for Neisseria gonorrhoeae, but none provide the combination of discrimination, reproducibility, portability, and genetic inference that allows the analysis of all aspect...

    Authors: Julia S Bennett, Keith A Jolley, P Frederick Sparling, Nigel J Saunders, C Anthony Hart, Ian M Feavers and Martin CJ Maiden

    Citation: BMC Biology 2007 5:35

    Content type: Research article

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  23. Over the last two decades, zebrafish have been established as a genetically versatile model system for investigating many different aspects of vertebrate developmental biology. With the credentials of zebrafis...

    Authors: Robert J Bryson-Richardson, Silke Berger, Thomas F Schilling, Thomas E Hall, Nicholas J Cole, Abigail J Gibson, James Sharpe and Peter D Currie

    Citation: BMC Biology 2007 5:34

    Content type: Research article

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  24. Upstream open reading frames (uORFs) can mediate translational control over the largest, or major ORF (mORF) in response to starvation, polyamine concentrations, and sucrose concentrations. One plant uORF with...

    Authors: Celine A Hayden and Richard A Jorgensen

    Citation: BMC Biology 2007 5:32

    Content type: Research article

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  25. Ancient whole genome duplications have been implicated in the vertebrate and teleost radiations, and in the emergence of diverse angiosperm lineages, but the evolutionary response to such a perturbation is sti...

    Authors: Uffe Hellsten, Mustafa K Khokha, Timothy C Grammer, Richard M Harland, Paul Richardson and Daniel S Rokhsar

    Citation: BMC Biology 2007 5:31

    Content type: Research article

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  26. Understanding the role of seascape in shaping genetic and demographic population structure is highly challenging for marine pelagic species such as cetaceans for which there is generally little evidence of wha...

    Authors: Michaël C Fontaine, Stuart JE Baird, Sylvain Piry, Nicolas Ray, Krystal A Tolley, Sarah Duke, Alexei Birkun Jr, Marisa Ferreira, Thierry Jauniaux, Ángela Llavona, Bayram Öztürk, Ayaka A Öztürk, Vincent Ridoux, Emer Rogan, Marina Sequeira, Ursula Siebert…

    Citation: BMC Biology 2007 5:30

    Content type: Research article

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  27. An important question is whether evolution favors properties such as mutational robustness or evolvability that do not directly benefit any individual, but can influence the course of future evolution. Functio...

    Authors: Jesse D Bloom, Zhongyi Lu, David Chen, Alpan Raval, Ophelia S Venturelli and Frances H Arnold

    Citation: BMC Biology 2007 5:29

    Content type: Research article

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  28. All previously reported eukaryotic nuclear genome sequences have been incomplete, especially in highly repeated units and chromosomal ends. Because repetitive DNA is important for many aspects of biology, comp...

    Authors: Hisayoshi Nozaki, Hiroyoshi Takano, Osami Misumi, Kimihiro Terasawa, Motomichi Matsuzaki, Shinichiro Maruyama, Keiji Nishida, Fumi Yagisawa, Yamato Yoshida, Takayuki Fujiwara, Susumu Takio, Katsunori Tamura, Sung Jin Chung, Soichi Nakamura, Haruko Kuroiwa, Kan Tanaka…

    Citation: BMC Biology 2007 5:28

    Content type: Research article

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  29. This article has been published as a correction for an error in the manuscript of Pavlov et al BMC Biology 2004, 2:11.

    Authors: Youri I Pavlov, Satoko Maki, Hisaji Maki and Thomas A Kunkel

    Citation: BMC Biology 2007 5:27

    Content type: Erratum

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    The original article was published in BMC Biology 2004 2:11

  30. Non-coding RNAs (ncRNAs) are an emerging focus for both computational analysis and experimental research, resulting in a growing number of novel, non-protein coding transcripts with often unknown functions. Wh...

    Authors: Stephan Steigele, Wolfgang Huber, Claudia Stocsits, Peter F Stadler and Kay Nieselt

    Citation: BMC Biology 2007 5:25

    Content type: Research article

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  31. Histone H1 is involved in the formation and maintenance of chromatin higher order structure. H1 has multiple isoforms; the subtypes differ in timing of expression, extent of phosphorylation and turnover rate. ...

    Authors: Mary Orrego, Imma Ponte, Alicia Roque, Natascha Buschati, Xavier Mora and Pedro Suau

    Citation: BMC Biology 2007 5:22

    Content type: Research article

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  32. Social and competitive demands often differ between the sexes in mammals. These differing demands should be expected to produce variation in the relative sizes of various brain structures. Sexual selection on ...

    Authors: Patrik Lindenfors, Charles L Nunn and Robert A Barton

    Citation: BMC Biology 2007 5:20

    Content type: Research article

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  33. A polymorphism in the activating component of the nicotinamide adenine dinucleotide phosphate (NADPH) oxidase complex, neutrophil cytosolic factor 1 (NCF1), has previously been identified as a regulator of art...

    Authors: Peter Olofsson, Annika Nerstedt, Malin Hultqvist, Elisabeth C Nilsson, Sofia Andersson, Anna Bergelin and Rikard Holmdahl

    Citation: BMC Biology 2007 5:19

    Content type: Research article

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  34. Cues predictive of food availability are powerful modulators of appetite as well as food-seeking and ingestive behaviors. The neurobiological underpinnings of these conditioned responses are not well understoo...

    Authors: Craig A Schiltz, Quentin Z Bremer, Charles F Landry and Ann E Kelley

    Citation: BMC Biology 2007 5:16

    Content type: Research article

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  35. The pygopus gene of Drosophila encodes an essential component of the Armadillo (β-catenin) transcription factor complex of canonical Wnt signaling. To better understand the functions of Pygopus-mediated canonical...

    Authors: Kristopher R Schwab, Larry T Patterson, Heather A Hartman, Ni Song, Richard A Lang, Xinhua Lin and S Steven Potter

    Citation: BMC Biology 2007 5:15

    Content type: Research article

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  36. Bacterial motility is a crucial factor in the colonization of natural environments. Escherichia coli has two flagella-driven motility types: swimming and swarming. Swimming motility consists of individual cell mo...

    Authors: José-María Gómez-Gómez, Candela Manfredi, Juan-Carlos Alonso and Jesús Blázquez

    Citation: BMC Biology 2007 5:14

    Content type: Research article

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