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  1. The downstream of tyrosine kinase/docking protein (Dok) adaptor protein family has seven members, Dok1 to Dok7, that act as substrates of multiple receptor tyrosine kinase and non-receptor tyrosine kinase. The...

    Authors: Wei qi Li, Lei Shi, Yuan gang You, Yan hua Gong, Bin Yin, Jian gang Yuan and Xiao zhong Peng
    Citation: BMC Biology 2010 8:86
  2. The identification of an increasing number of cancer genes is opening up unexpected scenarios in cancer genetics. When analyzed for their systemic properties, these genes show a general fragility towards pertu...

    Authors: Francesca D Ciccarelli
    Citation: BMC Biology 2010 8:74
  3. The Drosophila Male Specific Lethal (MSL) complex contains chromatin modifying enzymes and non-coding roX RNA. It paints the male X at hundreds of bands where it acetylates histone H4 at lysine 16. This epigeneti...

    Authors: Mahalakshmi Prabhakaran and Richard L Kelley
    Citation: BMC Biology 2010 8:80
  4. Among invertebrates, specific pheromones elicit inherent (fixed) behavioural responses to coordinate social behaviours such as sexual recognition and attraction. By contrast, the much more complex social odour...

    Authors: Sarah A Roberts, Deborah M Simpson, Stuart D Armstrong, Amanda J Davidson, Duncan H Robertson, Lynn McLean, Robert J Beynon and Jane L Hurst
    Citation: BMC Biology 2010 8:75
  5. A study in the current issue of BMC Biology has identified a mouse major urinary protein as a pheromone that attracts female mice to male urine marks and induces a learned attraction to the volatile urinary odor ...

    Authors: Peter A Brennan
    Citation: BMC Biology 2010 8:71
  6. Spartin protein is involved in degradation of epidermal growth factor receptor and turnover of lipid droplets and a lack of expression of this protein is responsible for hereditary spastic paraplegia type 20 (...

    Authors: Christopher Hooper, Swamy S Puttamadappa, Zak Loring, Alexander Shekhtman and Joanna C Bakowska
    Citation: BMC Biology 2010 8:72
  7. To elucidate the biological processes affected by changes in growth rate and nutrient availability, we have performed a comprehensive analysis of the transcriptome, proteome and metabolome responses of chemost...

    Authors: Alex Gutteridge, Pınar Pir, Juan I Castrillo, Philip D Charles, Kathryn S Lilley and Stephen G Oliver
    Citation: BMC Biology 2010 8:68
  8. A recent paper published in BMC Genomics suggests that retrotransposition may be active in the human gut parasite Entamoeba histolytica. This adds to our knowledge of the various types of repetitive elements in p...

    Authors: Christine Clayton
    Citation: BMC Biology 2010 8:64
  9. A recent article in BMC Biology illustrates the use of a systems-biology approach to integrate data across the transcriptome, proteome and metabolome of budding yeast in order to dissect the relationship between ...

    Authors: Teresa M Przytycka and Justen Andrews
    Citation: BMC Biology 2010 8:62
  10. After a volcano erupts, a lake may form in the cooled crater and become an isolated aquatic ecosystem. This makes fishes in crater lakes informative for understanding sympatric evolution and ecological diversi...

    Authors: Kathryn R Elmer, Topi K Lehtonen, Andreas F Kautt, Chris Harrod and Axel Meyer
    Citation: BMC Biology 2010 8:60

    The Erratum to this article has been published in BMC Biology 2012 10:70

  11. Ultra-high throughput sequencing technologies provide opportunities both for discovery of novel molecular species and for detailed comparisons of gene expression patterns. Small RNA populations are particularl...

    Authors: Daniela Witten, Robert Tibshirani, Sam Guoping Gu, Andrew Fire and Weng-Onn Lui
    Citation: BMC Biology 2010 8:58
  12. Small interfering RNAs can trigger unintended, microRNA-like off-target effects, but the impact of these effects on functional studies has been controversial. A recent study in BMC Genomics shows that microRNA-li...

    Authors: Peter S Linsley and Aimee L Jackson
    Citation: BMC Biology 2010 8:53
  13. The interfacial molecular mechanisms that regulate mammalian cell growth and differentiation have important implications for biotechnology (production of cells and cell products) and medicine (tissue engineeri...

    Authors: Elizabeth A Mitchell, Benjamin T Chaffey, Andrew W McCaskie, Jeremy H Lakey and Mark A Birch
    Citation: BMC Biology 2010 8:57
  14. Transcription is the first step of gene expression and is characterized by a high fidelity of RNA synthesis. During transcription, the RNA polymerase active centre discriminates against not just non-complement...

    Authors: Yulia Yuzenkova, Aleksandra Bochkareva, Vasisht R Tadigotla, Mohammad Roghanian, Savva Zorov, Konstantin Severinov and Nikolay Zenkin
    Citation: BMC Biology 2010 8:54
  15. Next-generation sequencing can be used to compare transcriptomes under different conditions. A study in BMC Genomics applies this approach to investigating the effects of exposure to a range of xenobiotics on cha...

    Authors: John Vontas, Hilary Ranson and Luke Alphey
    Citation: BMC Biology 2010 8:52
  16. The phylogenetic systematics of bovin species forms a common basis for studies at multiple scales, from the level of domestication in populations to major cladogenesis. The main big-picture accomplishments of ...

    Authors: Faysal Bibi and Elisabeth S Vrba
    Citation: BMC Biology 2010 8:50
  17. Molecular interaction networks provide a window on the workings of the cell. However, combining various types of networks into one coherent large-scale dynamic model remains a formidable challenge. A recent pa...

    Authors: Teresa M Przytycka and Yoo-Ah Kim
    Citation: BMC Biology 2010 8:48
  18. In mammalian cells, the integrity of the primary cilium is critical for proper regulation of the Hedgehog (Hh) signal transduction pathway. Whether or not this dependence on the primary cilium is a universal f...

    Authors: Hyejeong Rosemary Kim, Joanna Richardson, Freek van Eeden and Philip W Ingham
    Citation: BMC Biology 2010 8:65
  19. A culture's icons are a window onto its soul. Few would disagree that, in the culture of molecular biology that dominated much of the life sciences for the last third of the 20th century, the dominant icon was...

    Authors: Arthur D Lander
    Citation: BMC Biology 2010 8:40
  20. Most of the significant recent advances in cancer treatment have been based on the great strides that have been made in our understanding of the underlying biology of the disease. Nevertheless, the exploitatio...

    Authors: Christopher J Lord and Alan Ashworth
    Citation: BMC Biology 2010 8:38
  21. The various tasks of visual systems, including course control, collision avoidance and the detection of small objects, require at the neuronal level the dendritic integration and subsequent processing of many ...

    Authors: Christian Spalthoff, Martin Egelhaaf, Philip Tinnefeld and Rafael Kurtz
    Citation: BMC Biology 2010 8:36
  22. One of the four principal categories of cell-cell junctions that hold together and shape distinct tissues and organs in vertebrates, adherens junctions (AJs) form cell-cell contacts that connect transmembrane ...

    Authors: Matthias M Falk
    Citation: BMC Biology 2010 8:34
  23. Neoplastic overgrowth depends on the cooperation of several mutations ultimately leading to major rearrangements in cellular behaviour. Precancerous cells are often removed by cell death from normal tissues in...

    Authors: Francesca Froldi, Marcello Ziosi, Flavio Garoia, Andrea Pession, Nicola A Grzeschik, Paola Bellosta, Dennis Strand, Helena E Richardson, Annalisa Pession and Daniela Grifoni
    Citation: BMC Biology 2010 8:33