Citation: BMC Biology 2018 16:135
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Ksenia Krasileva is an Assistant Professor at UC Berkeley, studying innate immunity in plants. Ksenia’s work combines plant genomics and plant-microbe interactions with new technologies, spanning basic studies...
Citation: BMC Biology 2018 16:123
Correction to: The introduction history of invasive garden ants in Europe: integrating genetic, chemical and behavioural approaches
Reinvestigation of the raw data revealed an unfortunate error in Ugelvig et al. 2008 .
Citation: BMC Biology 2018 16:128
The study of ancient DNA is hampered by degradation, resulting in short DNA fragments. Advances in laboratory methods have made it possible to retrieve short DNA fragments, thereby improving access to DNA pres...
Citation: BMC Biology 2018 16:121
Microtubule polyglutamylation and acetylation drive microtubule dynamics critical for platelet formation
Upon maturation in the bone marrow, polyploid megakaryocytes elongate very long and thin cytoplasmic branches called proplatelets. Proplatelets enter the sinusoids blood vessels in which platelets are ultimate...
Citation: BMC Biology 2018 16:116
The ability of certain tumor cells of mammals and molluscs to spread from the original host to others reopens the question of distinguishing self from non-self. It is part of a wider phenomenon of cellular par...
Citation: BMC Biology 2018 16:115
High throughput methods for profiling the transcriptomes of single cells have recently emerged as transformative approaches for large-scale population surveys of cellular diversity in heterogeneous primary tis...
Citation: BMC Biology 2018 16:113
Food perception without ingestion leads to metabolic changes and irreversible developmental arrest in C. elegans
Developmental physiology is very sensitive to nutrient availability. For instance, in the nematode Caenorhabditis elegans, newly hatched L1-stage larvae require food to initiate postembryonic development. In addi...
Citation: BMC Biology 2018 16:112
UBN1/2 of HIRA complex is responsible for recognition and deposition of H3.3 at cis-regulatory elements of genes in mouse ES cells
H3.3 is an ancient and conserved H3 variant and plays essential roles in transcriptional regulation. HIRA complex, which is composed of HIRA, UBN1 or UBN2, and Cabin1, is a H3.3 specific chaperone complex. How...
Citation: BMC Biology 2018 16:110
The WW domain-containing oxidoreductase (WWOX) gene, frequently altered in breast cancer, encodes a tumor suppressor whose function is mediated through its interactions with cancer-related proteins, such as the p...
Citation: BMC Biology 2018 16:109
Cell type-specific expression profiling unravels the development and evolution of stinging cells in sea anemone
Cnidocytes are specialized cells that define the phylum Cnidaria. They possess an “explosive” organelle called cnidocyst that is important for prey capture and anti-predator defense. An extraordinary morpholog...
Citation: BMC Biology 2018 16:108
During hearing in mammals, “sensorineural” inner hair cells convert sound wave-generated mechanical input into electrical activity, resulting in glutamate release onto type I spiral ganglion neurons (SGNs) at ...
Citation: BMC Biology 2018 16:105
Synaptic coupling of inner ear sensory cells is controlled by brevican-based extracellular matrix baskets resembling perineuronal nets
Perineuronal nets (PNNs) are specialized aggregations of extracellular matrix (ECM) molecules surrounding specific neurons in the central nervous system (CNS). PNNs are supposed to control synaptic transmissio...
Citation: BMC Biology 2018 16:99
Sexual reproduction is costly compared to asexual reproduction, in particular because males generally contribute little to offspring. Research published today in BMC Biology shows that some populations of a termi...
Citation: BMC Biology 2018 16:106
Sexual reproduction is the norm in almost all animal species, and in many advanced animal societies, both males and females participate in social activities. To date, the complete loss of males from advanced s...
Citation: BMC Biology 2018 16:96
Histone variants H2A.Z and H3.3 coordinately regulate PRC2-dependent H3K27me3 deposition and gene expression regulation in mES cells
The hierarchical organization of eukaryotic chromatin plays a central role in gene regulation, by controlling the extent to which the transcription machinery can access DNA. The histone variants H3.3 and H2A.Z...
Citation: BMC Biology 2018 16:107
CRISPR-Cas systems, the purveyors of adaptive immunity in archaea and bacteria and sources of the new generation of genome engineering tools, have been studied in exquisite molecular detail. However, when it c...
Citation: BMC Biology 2018 16:95
Defining the mechanisms that establish and regulate the transmission of epigenetic information from parent to offspring is critical for understanding disease heredity. Currently, the molecular pathways that re...
Citation: BMC Biology 2018 16:104
The piRNA pathway responds to environmental signals to establish intergenerational adaptation to stress
piRNAs have a constitutive role in genome defence by silencing transposable elements in the germline. In the nematode Caenorhabditis elegans, piRNAs also induce epigenetic silencing of transgenes, which can be ma...
Citation: BMC Biology 2018 16:103
Genome sequencing of rice subspecies and genetic analysis of recombinant lines reveals regional yield- and quality-associated loci
Two of the most widely cultivated rice strains are Oryza sativa indica and O. sativa japonica, and understanding the genetic basis of their agronomic traits is of importance for crop production. These two species...
Citation: BMC Biology 2018 16:102
Global analyses of gene expression during development reveal specific transcription patterns associated with the emergence of various cell types, tissues, and organs. These heterogeneous patterns are instrumen...
Citation: BMC Biology 2018 16:101
Parkinson’s disease (PD)-associated E3 ubiquitin ligase Parkin is enriched at glutamatergic synapses, where it ubiquitinates multiple substrates, suggesting that its mutation/loss-of-function could contribute ...
Citation: BMC Biology 2018 16:100
Array tomography encompasses light and electron microscopy modalities that offer unparalleled opportunities to explore three-dimensional cellular architectures in extremely fine structural and molecular detail...
Citation: BMC Biology 2018 16:98
Biologists have long been fascinated by the striking diversity of complex color patterns in tropical reef fishes. However, the origins and evolution of this diversity are still poorly understood. Disentangling...
Citation: BMC Biology 2018 16:90
Microdomain formation is a general property of bacterial membrane proteins and induces heterogeneity of diffusion patterns
Proteins within the cytoplasmic membrane display distinct localization patterns and arrangements. While multiple models exist describing the dynamics of membrane proteins, to date, there have been few systemat...
Citation: BMC Biology 2018 16:97
Seventeen years after the initial publication of the human genome, we still haven’t found all of our genes. The answer turns out to be more complex than anyone had imagined when the Human Genome Project began.
Citation: BMC Biology 2018 16:94
Between the 1930s and 50s, evolutionary biologists developed a successful theory of why organisms age, firmly rooted in population genetic principles. By the 1980s the evolution of aging had a secure experimen...
Citation: BMC Biology 2018 16:93
Increased activity of the receptor tyrosine kinase Tie2 has been implicated in the promotion of pathological angiogenesis. This activity is mainly mediated through angiopoietin (Ang)1- and Ang2-dependent activ...
Citation: BMC Biology 2018 16:92
A unified resource for transcriptional regulation in Escherichia coli K-12 incorporating high-throughput-generated binding data into RegulonDB version 10.0
Our understanding of the regulation of gene expression has benefited from the availability of high-throughput technologies that interrogate the whole genome for the binding of specific transcription factors an...
Citation: BMC Biology 2018 16:91
Clonal raider ant brain transcriptomics identifies candidate molecular mechanisms for reproductive division of labor
Division of labor between reproductive queens and workers that perform brood care is a hallmark of insect societies. However, studies of the molecular basis of this fundamental dichotomy are limited by the fac...
Citation: BMC Biology 2018 16:89
The ubiquitin-proteasome system (UPS) controls the stability, localization and/or activity of the proteome. However, the identification and characterization of complex individual ubiquitination cascades and th...
Citation: BMC Biology 2018 16:88
Evolutionary stability of topologically associating domains is associated with conserved gene regulation
The human genome is highly organized in the three-dimensional nucleus. Chromosomes fold locally into topologically associating domains (TADs) defined by increased intra-domain chromatin contacts. TADs contribu...
Citation: BMC Biology 2018 16:87
Attention decouples action potentials from the phase of local field potentials in macaque visual cortical area MT
The timing of action potentials (“spikes”) of cortical neurons has been shown to be aligned to the phase of low-frequency (< 10 Hz) local field potentials (LFPs) in several cortical areas. However, across the ...
Citation: BMC Biology 2018 16:86
Structural and functional characterization of protein–lipid interactions of the Salmonella typhimurium melibiose transporter MelB
Membrane lipids play critical roles in the structure and function of membrane-embedded transporters. Salmonella typhimurium MelB (MelBSt) is a symporter coupling melibiose translocation with a cation (Na+, Li+, o...
Citation: BMC Biology 2018 16:85
A GWAS on Helicobacter pylori strains points to genetic variants associated with gastric cancer risk
Helicobacter pylori are stomach-dwelling bacteria that are present in about 50% of the global population. Infection is asymptomatic in most cases, but it has been associated with gastritis, gastric ulcers and gas...
Citation: BMC Biology 2018 16:84
Mammals display a wide range of variation in their lifespan. Investigating the molecular networks that distinguish long- from short-lived species has proven useful to identify determinants of longevity. Here, ...
Citation: BMC Biology 2018 16:82
Naked mole-rat transcriptome signatures of socially suppressed sexual maturation and links of reproduction to aging
Naked mole-rats (NMRs) are eusocially organized in colonies. Although breeders carry the additional metabolic load of reproduction, they are extremely long-lived and remain fertile throughout their lifespan. T...
Citation: BMC Biology 2018 16:77
Additive contributions of melanopsin and both cone types provide broadband sensitivity to mouse pupil control
Intrinsically photosensitive retinal ganglion cells (ipRGCs) drive an array of non-image-forming (NIF) visual responses including circadian photoentrainment and the pupil light reflex. ipRGCs integrate extrins...
Citation: BMC Biology 2018 16:83
Mitochondria are sensitive to numerous environmental stresses, which can lead to activation of mitochondrial stress responses (MSRs). Of particular recent interest has been the mitochondrial unfolded protein r...
Citation: BMC Biology 2018 16:81
Stable predictive markers for Phytophthora sojae avirulence genes that impair infection of soybean uncovered by whole genome sequencing of 31 isolates
The interaction between oomycete plant pathogen Phytophthora sojae and soybean is characterized by the presence of avirulence (Avr) genes in P. sojae, which encode for effectors that trigger immune responses and ...
Citation: BMC Biology 2018 16:80
The neural plate border ectoderm gives rise to key developmental structures during embryogenesis, including the neural crest and the preplacodal ectoderm. Many sensory organs and ganglia of vertebrates develop...
Citation: BMC Biology 2018 16:79
Transposable element insertions shape gene regulation and melanin production in a fungal pathogen of wheat
Fungal plant pathogens pose major threats to crop yield and sustainable food production if they are highly adapted to their host and the local environment. Variation in gene expression contributes to phenotypi...
Citation: BMC Biology 2018 16:78
Structural complexity of the co-chaperone SGTA: a conserved C-terminal region is implicated in dimerization and substrate quality control
Protein quality control mechanisms are essential for cell health and involve delivery of proteins to specific cellular compartments for recycling or degradation. In particular, stray hydrophobic proteins are c...
Citation: BMC Biology 2018 16:76
RNA-guided CRISPR/Cas9 systems can be designed to mutate or excise the integrated HIV genome from latently infected cells and have therefore been proposed as a curative approach for HIV. However, most studies ...
Citation: BMC Biology 2018 16:75
Genome-wide knockout studies, noncoding deletion scans, and other large-scale studies require a simple and lightweight framework that can quickly discover and score thousands of candidate CRISPR guides targeti...
Citation: BMC Biology 2018 16:74
In mammalian females, progressive activation of dormant primordial follicles in adulthood is crucial for the maintenance of the reproductive lifespan. Misregulated activation of primordial follicles leads to v...
Citation: BMC Biology 2018 16:73
Unique sperm haplotypes are associated with phenotypically different sperm subpopulations in Astyanax fish
The phenotypes of sperm are generally believed to be under the control of the diploid genotype of the male producing them rather than their own haploid genotypes, because developing spermatids share cytoplasm ...
Citation: BMC Biology 2018 16:72
Comparison of village dog and wolf genomes highlights the role of the neural crest in dog domestication
Domesticated from gray wolves between 10 and 40 kya in Eurasia, dogs display a vast array of phenotypes that differ from their ancestors, yet mirror other domesticated animal species, a phenomenon known as the...
Citation: BMC Biology 2018 16:64
Huntington’s disease (HD) is one of the most common tandem repeat disorders and presents as a unique trilogy of cognitive, psychiatric and motor symptoms. One of the major mysteries of HD is why it selectively...
Citation: BMC Biology 2018 16:71
Altering cortical input unmasks synaptic phenotypes in the YAC128 cortico-striatal co-culture model of Huntington disease
Huntington disease (HD) is a fatal neurodegenerative disorder caused by a CAG expansion in the huntingtin (HTT) gene, leading to selective and progressive neuronal death predominantly in the striatum. Mutant HTT ...
Citation: BMC Biology 2018 16:58
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