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Page 7 of 31

  1. Protein–protein interactions (PPIs) are fundamental to the growth and survival of cells and serve as excellent targets to develop inhibitors of biological processes such as host-pathogen interactions and cance...

    Authors: Jin Huei Wong, Mohammad Alfatah, Mei Fang Sin, Hong May Sim, Chandra S. Verma, David P. Lane and Prakash Arumugam

    Citation: BMC Biology 2017 15:108

    Content type: Methodology article

    Published on:

  2. Many proteins of the mitochondrial intermembrane space (IMS) contain structural disulfide bonds formed by the mitochondrial disulfide relay. In fungi and animals, the sulfhydryl oxidase Erv1 ‘generates’ disulf...

    Authors: Valentina Peleh, Flavien Zannini, Sandra Backes, Nicolas Rouhier and Johannes M. Herrmann

    Citation: BMC Biology 2017 15:106

    Content type: Research article

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  3. TRIM25 is a novel RNA-binding protein and a member of the Tripartite Motif (TRIM) family of E3 ubiquitin ligases, which plays a pivotal role in the innate immune response. However, there is scarce knowledge ab...

    Authors: Nila Roy Choudhury, Gregory Heikel, Maryia Trubitsyna, Peter Kubik, Jakub Stanislaw Nowak, Shaun Webb, Sander Granneman, Christos Spanos, Juri Rappsilber, Alfredo Castello and Gracjan Michlewski

    Citation: BMC Biology 2017 15:105

    Content type: Research article

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  4. Neural activity in the vertebrate habenula is affected by ambient illumination. The nucleus that links photoreceptor activity with the habenula is not well characterized. Here, we describe the location, inputs...

    Authors: Ruey-Kuang Cheng, Seetha Krishnan, Qian Lin, Caroline Kibat and Suresh Jesuthasan

    Citation: BMC Biology 2017 15:104

    Content type: Research article

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  5. Optical silencing of activity provides a way to test the necessity of neurons in behaviour. Two light-gated anion channels, GtACR1 and GtACR2, have recently been shown to potently inhibit activity in cultured ...

    Authors: Gadisti Aisha Mohamed, Ruey-Kuang Cheng, Joses Ho, Seetha Krishnan, Farhan Mohammad, Adam Claridge-Chang and Suresh Jesuthasan

    Citation: BMC Biology 2017 15:103

    Content type: Methodology article

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  6. Discoveries spanning several decades have pointed to vital membrane lipid trafficking pathways involving both vesicular and non-vesicular carriers. But the relative contributions for distinct membrane delivery...

    Authors: Christopher J. Stefan, William S. Trimble, Sergio Grinstein, Guillaume Drin, Karin Reinisch, Pietro De Camilli, Sarah Cohen, Alex M. Valm, Jennifer Lippincott-Schwartz, Tim P. Levine, David B. Iaea, Frederick R. Maxfield, Clare E. Futter, Emily R. Eden, Delphine Judith, Alexander R. van Vliet…

    Citation: BMC Biology 2017 15:102

    Content type: Forum

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  7. Imaging as a means of scientific data storage has evolved rapidly over the past century from hand drawings, to photography, to digital images. Only recently can sufficiently large datasets be acquired, stored,...

    Authors: Josh L. Morgan and Jeff W. Lichtman

    Citation: BMC Biology 2017 15:101

    Content type: Review

    Published on:

  8. Internal tagging of proteins by inserting small functional peptides into surface accessible permissive sites has proven to be an indispensable tool for basic and applied science. Permissive sites are typically...

    Authors: Sabine Oesterle, Tania Michelle Roberts, Lukas Andreas Widmer, Harun Mustafa, Sven Panke and Sonja Billerbeck

    Citation: BMC Biology 2017 15:100

    Content type: Methodology article

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  9. The MultiBac baculovirus/insect cell expression vector system was conceived as a user-friendly, modular tool-kit for producing multiprotein complexes for structural biology applications. MultiBac has allowed t...

    Authors: Martin Pelosse, Hannah Crocker, Barbara Gorda, Paul Lemaire, Jens Rauch and Imre Berger

    Citation: BMC Biology 2017 15:99

    Content type: Review

    Published on:

  10. Population geneticists have long sought to understand the contribution of natural selection to molecular evolution. A variety of approaches have been proposed that use population genetics theory to quantify th...

    Authors: Tom R. Booker, Benjamin C. Jackson and Peter D. Keightley

    Citation: BMC Biology 2017 15:98

    Content type: Review

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  11. In a macro-molecular complex, any minor change may prove detrimental. For a supra-molecular nano-machine like the bacterial flagellum, which consists of several distinct parts with specific characteristics, st...

    Authors: Clive S. Barker, Irina V. Meshcheryakova, Alla S. Kostyukova, Peter L. Freddolino and Fadel A. Samatey

    Citation: BMC Biology 2017 15:97

    Content type: Research article

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  12. California is a world floristic biodiversity hotspot where the terms neo- and paleo-endemism were first applied. Using spatial phylogenetics, it is now possible to evaluate biodiversity from an evolutionary st...

    Authors: Andrew H. Thornhill, Bruce G. Baldwin, William A. Freyman, Sonia Nosratinia, Matthew M. Kling, Naia Morueta-Holme, Thomas P. Madsen, David D. Ackerly and Brent D. Mishler

    Citation: BMC Biology 2017 15:96

    Content type: Research article

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  13. Signaling pathways direct organogenesis, often through concentration-dependent effects on cells. The hedgehog pathway enables cells to sense and respond to hedgehog ligands, of which the best studied is sonic ...

    Authors: Robert Blassberg and John Jacob

    Citation: BMC Biology 2017 15:95

    Content type: Review

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  14. Mitochondria are predominantly inherited from the maternal gamete, even in unicellular organisms. Yet an extraordinary array of mechanisms enforce uniparental inheritance, which implies shifting selection pres...

    Authors: Arunas L. Radzvilavicius, Nick Lane and Andrew Pomiankowski

    Citation: BMC Biology 2017 15:94

    Content type: Research article

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  15. Apoptosis is a form of programmed cell death that is carried out by proteolytic enzymes called caspases. Executioner caspase activity causes cells to shrink, bleb, and disintegrate into apoptotic bodies and ha...

    Authors: Gongping Sun and Denise J. Montell

    Citation: BMC Biology 2017 15:92

    Content type: Question and Answer

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  16. Proper DNA replication is essential for faithful transmission of the genome. However, replication stress has serious impact on the integrity of the cell, leading to stalling or collapse of replication forks, a...

    Authors: Alexandra Sisakova, Veronika Altmannova, Marek Sebesta and Lumir Krejci

    Citation: BMC Biology 2017 15:90

    Content type: Research article

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  17. What made us human? Gene expression changes clearly played a significant part in human evolution, but pinpointing the causal regulatory mutations is hard. Comparative genomics enabled the identification of hum...

    Authors: Lucía F. Franchini and Katherine S. Pollard

    Citation: BMC Biology 2017 15:89

    Content type: Review

    Published on:

  18. Mate finding and recognition in animals evolves during niche adaptation and involves social signals and habitat cues. Drosophila melanogaster and related species are known to be attracted to fermenting fruit for ...

    Authors: Sebastien Lebreton, Felipe Borrero-Echeverry, Francisco Gonzalez, Marit Solum, Erika A. Wallin, Erik Hedenström, Bill S. Hansson, Anna-Lena Gustavsson, Marie Bengtsson, Göran Birgersson, William B. Walker III, Hany K. M. Dweck, Paul G. Becher and Peter Witzgall

    Citation: BMC Biology 2017 15:88

    Content type: Research article

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  19. Mammalian organs comprise a variety of cells that interact with each other and have distinct biological roles. Access to evaluate and perturb intact biological systems at the cellular and molecular levels is e...

    Authors: Alon Greenbaum, Min J. Jang, Collin Challis and Viviana Gradinaru

    Citation: BMC Biology 2017 15:87

    Content type: Question and Answer

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  20. Root and tuber crops are a major food source in tropical Africa. Among these crops are several species in the monocotyledonous genus Dioscorea collectively known as yam, a staple tuber crop that contributes enorm...

    Authors: Muluneh Tamiru, Satoshi Natsume, Hiroki Takagi, Benjamen White, Hiroki Yaegashi, Motoki Shimizu, Kentaro Yoshida, Aiko Uemura, Kaori Oikawa, Akira Abe, Naoya Urasaki, Hideo Matsumura, Pachakkil Babil, Shinsuke Yamanaka, Ryo Matsumoto, Satoru Muranaka…

    Citation: BMC Biology 2017 15:86

    Content type: Research

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  21. Antibiotic natural products are ancient and so is resistance. Consequently, environmental bacteria harbor numerous and varied antibiotic resistance elements. Nevertheless, despite long histories of antibiotic ...

    Authors: Nicholas Waglechner and Gerard D. Wright

    Citation: BMC Biology 2017 15:84

    Content type: Review

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  22. In this question and answer article we discuss how evolution shapes morphology (the shape and pattern of our bodies) but also how learning about morphology, and specifically how that morphology arises during d...

    Authors: Neal Anthwal and Abigail S. Tucker

    Citation: BMC Biology 2017 15:83

    Content type: Question and Answer

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  23. Neurons relevant to a particular behavior are often widely dispersed across the brain. To record activity in groups of individual neurons that might be distributed across large distances, neuroscientists and o...

    Authors: Nicholas James Sofroniew

    Citation: BMC Biology 2017 15:82

    Content type: Question and Answer

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  24. Similar to other eukaryotes, splicing is emerging as an important process affecting development and stress tolerance in plants. Ski-interacting protein (SKIP), a splicing factor, is essential for circadian clo...

    Authors: Zhibo Cui, Aizi Tong, Yiqiong Huo, Zhiqiang Yan, Weiqi Yang, Xianli Yang and Xiao-Xue Wang

    Citation: BMC Biology 2017 15:80

    Content type: Research article

    Published on:

    The Correction to this article has been published in BMC Biology 2019 17:25

  25. Members of the thioester-containing protein (TEP) family contribute to host defence in both insects and mammals. However, their role in the immune response of Drosophila is elusive. In this study, we address the ...

    Authors: Anna Dostálová, Samuel Rommelaere, Mickael Poidevin and Bruno Lemaitre

    Citation: BMC Biology 2017 15:79

    Content type: Research article

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  26. For a subset of genes in our genome a change in gene dosage, by duplication or deletion, causes a phenotypic effect. These dosage-sensitive genes may confer an advantage upon copy number change, but more typic...

    Authors: Alan M. Rice and Aoife McLysaght

    Citation: BMC Biology 2017 15:78

    Content type: Review

    Published on:

  27. Genomic evidence has demonstrated that humans and Neanderthals interbred. Today, the genomes of most individuals outside Africa contain 2–3% Neanderthal DNA. However, it is still hotly debated why the Neandert...

    Authors: Kelley Harris and Rasmus Nielsen

    Citation: BMC Biology 2017 15:73

    Content type: Question and Answer

    Published on:

  28. Amaranth (Amaranthus hypochondriacus) was a food staple among the ancient civilizations of Central and South America that has recently received increased attention due to the high nutritional value of the seeds, ...

    Authors: D. J. Lightfoot, D. E. Jarvis, T. Ramaraj, R. Lee, E. N. Jellen and P. J. Maughan

    Citation: BMC Biology 2017 15:74

    Content type: Research article

    Published on:

  29. While methods for annotation of genes are increasingly reliable, the exact identification of translation initiation sites remains a challenging problem. Since the N-termini of proteins often contain regulatory...

    Authors: Adam Giess, Veronique Jonckheere, Elvis Ndah, Katarzyna Chyżyńska, Petra Van Damme and Eivind Valen

    Citation: BMC Biology 2017 15:76

    Content type: Research article

    Published on:

  30. Polymorphic toxins (PTs) are multi-domain bacterial exotoxins belonging to distinct families that share common features in terms of domain organization. PTs are found in all major bacterial clades, including m...

    Authors: Anne Jamet, Marie Touchon, Bruno Ribeiro-Gonçalves, João André Carriço, Alain Charbit, Xavier Nassif, Mario Ramirez and Eduardo P. C. Rocha

    Citation: BMC Biology 2017 15:75

    Content type: Research article

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  31. Disrupting sleep during development leads to lasting deficits in chordates and arthropods. To address lasting impacts of sleep deprivation in Caenorhabditis elegans, we established a nonlethal deprivation protoco...

    Authors: Jarred Sanders, Monika Scholz, Ilaria Merutka and David Biron

    Citation: BMC Biology 2017 15:67

    Content type: Research article

    Published on:

  32. The phylum Apicomplexa includes intracellular parasites causing immense global disease burden, the deadliest of them being the human malaria parasite Plasmodium falciparum, which invades and replicates within ery...

    Authors: Sujaan Das, Leandro Lemgruber, Chwen L. Tay, Jake Baum and Markus Meissner

    Citation: BMC Biology 2017 15:70

    Content type: Research article

    Published on:

  33. Authors: S. L. Pearce, D. F. Clarke, P. D. East, S. Elfekih, K. H. J. Gordon, L. S. Jermiin, A. McGaughran, J. G. Oakeshott, A. Papanicolaou, O. P. Perera, R. V. Rane, S. Richards, W. T. Tay, T. K. Walsh, A. Anderson, C. J. Anderson…

    Citation: BMC Biology 2017 15:69

    Content type: Erratum

    Published on:

    The original article was published in BMC Biology 2017 15:63

  34. Helicoverpa armigera and Helicoverpa zea are major caterpillar pests of Old and New World agriculture, respectively. Both, particularly H. armigera, are extremely polyphagous, and H. a...

    Authors: S. L. Pearce, D. F. Clarke, P. D. East, S. Elfekih, K. H. J. Gordon, L. S. Jermiin, A. McGaughran, J. G. Oakeshott, A. Papanikolaou, O. P. Perera, R. V. Rane, S. Richards, W. T. Tay, T. K. Walsh, A. Anderson, C. J. Anderson…

    Citation: BMC Biology 2017 15:63

    Content type: Research article

    Published on:

    The Erratum to this article has been published in BMC Biology 2017 15:69

  35. The duplication of genes can occur through various mechanisms and is thought to make a major contribution to the evolutionary diversification of organisms. There is increasing evidence for a large-scale duplic...

    Authors: Evelyn E. Schwager, Prashant P. Sharma, Thomas Clarke, Daniel J. Leite, Torsten Wierschin, Matthias Pechmann, Yasuko Akiyama-Oda, Lauren Esposito, Jesper Bechsgaard, Trine Bilde, Alexandra D. Buffry, Hsu Chao, Huyen Dinh, HarshaVardhan Doddapaneni, Shannon Dugan, Cornelius Eibner…

    Citation: BMC Biology 2017 15:62

    Content type: Research article

    Published on:

  36. Transmembrane helices (TMHs) frequently occur amongst protein architectures as means for proteins to attach to or embed into biological membranes. Physical constraints such as the membrane’s hydrophobicity and...

    Authors: James Alexander Baker, Wing-Cheong Wong, Birgit Eisenhaber, Jim Warwicker and Frank Eisenhaber

    Citation: BMC Biology 2017 15:66

    Content type: Research article

    Published on:

    The Erratum to this article has been published in BMC Biology 2017 15:72

  37. Biological mineral formation (biomineralization) proceeds in specialized compartments often bounded by a lipid bilayer membrane. Currently, the role of membranes in biomineralization is hardly understood.

    Authors: Alexander Kotzsch, Philip Gröger, Damian Pawolski, Paul H. H. Bomans, Nico A. J. M. Sommerdijk, Michael Schlierf and Nils Kröger

    Citation: BMC Biology 2017 15:65

    Content type: Research article

    Published on:

  38. In addition to DNA, gametes contribute epigenetic information in the form of histones and non-coding RNA. Epigenetic programs often respond to stressful environmental conditions and provide a heritable history...

    Authors: Wendy L. Johnston, Aldis Krizus, Arun K. Ramani, Wade Dunham, Ji Young Youn, Andrew G. Fraser, Anne-Claude Gingras and James W. Dennis

    Citation: BMC Biology 2017 15:61

    Content type: Research article

    Published on:

  39. There is increasing evidence that all cells sense mechanical forces in order to perform their functions. In animals, mechanotransduction has been studied during the establishment of cell polarity, fate, and di...

    Authors: Olivier Hamant and Elizabeth S. Haswell

    Citation: BMC Biology 2017 15:59

    Content type: Review

    Published on:

  40. Individual neurons vary widely in terms of their gene expression, morphology, and electrophysiological properties. While many techniques exist to study single-cell variability along one or two of these dimensi...

    Authors: Cathryn R. Cadwell, Rickard Sandberg, Xiaolong Jiang and Andreas S. Tolias

    Citation: BMC Biology 2017 15:58

    Content type: Question and Answer

    Published on:

    The Related Article to this article has been published in Nature Protocols 2017 12:BFnprot2017120

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