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  1. Content type: Research article

    Peptide transporters are membrane proteins that mediate the cellular uptake of di- and tripeptides, and of peptidomimetic drugs such as β-lactam antibiotics, antiviral drugs and antineoplastic agents. In spite...

    Authors: Rajendra Boggavarapu, Jean-Marc Jeckelmann, Daniel Harder, Zöhre Ucurum and Dimitrios Fotiadis

    Citation: BMC Biology 2015 13:58

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  2. Content type: Comment

    Some steroid drugs are designed for clinical use to combat muscle-wasting diseases, but are also used by athletes to improve their performance by increasing muscle strength or endurance. This study investigate...

    Authors: Emma Saxon

    Citation: BMC Biology 2015 13:61

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  3. Content type: Comment

    Probiotic treatments are thought to increase the levels of commensal bacterial species that populate the human gut, causing no harm to their host and playing an important role in maintaining gut health. This s...

    Authors: Emma Saxon

    Citation: BMC Biology 2015 13:60

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  4. Content type: Research article

    The functional consequences of whole genome duplications in vertebrate evolution are not fully understood. It remains unclear, for instance, why paralogues were retained in some gene families but extensively l...

    Authors: Ferdinand Marlétaz, Ignacio Maeso, Laura Faas, Harry V. Isaacs and Peter W. H. Holland

    Citation: BMC Biology 2015 13:56

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  5. Content type: Research article

    The male germline transcriptome changes dramatically during the mitosis-to-meiosis transition to activate late spermatogenesis genes and to transiently suppress genes commonly expressed in somatic lineages and...

    Authors: Ho-Su Sin, Andrey V. Kartashov, Kazuteru Hasegawa, Artem Barski and Satoshi H. Namekawa

    Citation: BMC Biology 2015 13:53

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  6. Content type: Methodology article

    Qualitative and quantitative measurements of motor performance are essential for characterizing perturbations of motor systems. Although several methods exist for analyzing specific motor tasks, few behavioral...

    Authors: César S. Mendes, Imre Bartos, Zsuzsanna Márka, Turgay Akay, Szabolcs Márka and Richard S. Mann

    Citation: BMC Biology 2015 13:50

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  7. Content type: Research article

    Stem cells are thought to play a critical role in minimizing the accumulation of mutations, but it is not clear which strategies they follow to fulfill that performance objective. Slow cycling of stem cells pr...

    Authors: Michael Chiang, Amanda Cinquin, Adrian Paz, Edward Meeds, Christopher A. Price, Max Welling and Olivier Cinquin

    Citation: BMC Biology 2015 13:51

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  8. Content type: Research article

    Malaria invasion of red blood cells involves multiple parasite-specific targets that are easily accessible to inhibitory compounds, making it an attractive target for antimalarial development. However, no curr...

    Authors: Danny W Wilson, Christopher D Goodman, Brad E Sleebs, Greta E Weiss, Nienke WM de Jong, Fiona Angrisano, Christine Langer, Jake Baum, Brendan S Crabb, Paul R Gilson, Geoffrey I McFadden and James G Beeson

    Citation: BMC Biology 2015 13:52

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  9. Content type: Research article

    Development and evaluation of new insect pest management tools is critical for overcoming over-reliance upon, and growing resistance to, synthetic, biological and plant-expressed insecticides. For transgenic c...

    Authors: Tim Harvey-Samuel, Neil I. Morrison, Adam S. Walker, Thea Marubbi, Ju Yao, Hilda L. Collins, Kevin Gorman, T. G. Emyr Davies, Nina Alphey, Simon Warner, Anthony M. Shelton and Luke Alphey

    Citation: BMC Biology 2015 13:49

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  10. Content type: Methodology article

    Genetic ablation of target cells is a powerful tool to study the origins and functions of cells, tissue regeneration, or pathophysiology in a human disease model in vivo. Several methods for selective cell ablati...

    Authors: Fumiaki Obata, Shiho Tanaka, Soshiro Kashio, Hidenobu Tsujimura, Ryoichi Sato and Masayuki Miura

    Citation: BMC Biology 2015 13:48

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  11. Content type: Forum

    Mechanotransduction - how cells sense physical forces and translate them into biochemical and biological responses - is a vibrant and rapidly-progressing field, and is important for a broad range of biological...

    Authors: Ewa K. Paluch, Celeste M. Nelson, Nicolas Biais, Ben Fabry, Jens Moeller, Beth L. Pruitt, Carina Wollnik, Galina Kudryasheva, Florian Rehfeldt and Walter Federle

    Citation: BMC Biology 2015 13:47

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  12. Content type: Question and answer

    Plants are able to sense UV-B through the UV-B photoreceptor UVR8. UV-B photon absorption by a UVR8 homodimer leads to UVR8 monomerization and interaction with the downstream signaling factor COP1. This then i...

    Authors: Roman Ulm and Gareth I Jenkins

    Citation: BMC Biology 2015 13:45

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  13. Content type: Research article

    In many insect species, fitness trade-offs exist between maximizing body size and developmental speed. Understanding how various species evolve different life history strategies requires knowledge of the physi...

    Authors: Nicole E. Hatem, Zhou Wang, Keelin B. Nave, Takashi Koyama and Yuichiro Suzuki

    Citation: BMC Biology 2015 13:44

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  14. Content type: Research article

    Daily rhythms in mammals are programmed by a master clock in the suprachiasmatic nucleus (SCN). The SCN contains two main compartments (shell and core), but the role of each region in system-level coordination...

    Authors: Jennifer A. Evans, Ting-Chung Suen, Ben L. Callif, Andrew S. Mitchell, Oscar Castanon-Cervantes, Kimberly M. Baker, Ian Kloehn, Kenkichi Baba, Brett J. W. Teubner, J. Christopher Ehlen, Ketema N. Paul, Timothy J. Bartness, Gianluca Tosini, Tanya Leise and Alec J. Davidson

    Citation: BMC Biology 2015 13:43

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  15. Content type: Research article

    Adenomatous polyposis coli (Apc) is a tumor suppressor that inhibits Wnt/Ctnnb1. Mutations of Apc will not only lead to familial adenomatous polyposis with associated epithelial lesions, but will also cause aggre...

    Authors: Yongfeng Luo, Elie El Agha, Gianluca Turcatel, Hui Chen, Joanne Chiu, David Warburton, Saverio Bellusci, Bang-Ping Qian, Douglas B. Menke and Wei Shi

    Citation: BMC Biology 2015 13:42

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  16. Content type: Research article

    We report here the first genome-wide high-resolution polymorphism resource for non-human primate (NHP) association and linkage studies, constructed for the Caribbean-origin vervet monkey, or African green monk...

    Authors: Yu S. Huang, Vasily Ramensky, Susan K. Service, Anna J. Jasinska, Yoon Jung, Oi-Wa Choi, Rita M. Cantor, Nikoleta Juretic, Jessica Wasserscheid, Jay R. Kaplan, Matthew J. Jorgensen, Thomas D. Dyer, Ken Dewar, John Blangero, Richard K. Wilson, Wesley Warren…

    Citation: BMC Biology 2015 13:41

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  17. Content type: Research article

    The early stages of ovarian follicle formation—beginning with the breakdown of germ cell cysts and continuing with the formation of primordial follicles and transition to primary and secondary follicles—are cr...

    Authors: Yu Ren, Hitomi Suzuki, Krishna Jagarlamudi, Kayla Golnoski, Megan McGuire, Rita Lopes, Vassilis Pachnis and Aleksandar Rajkovic

    Citation: BMC Biology 2015 13:39

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  18. Content type: Research article

    Chromosomes reorganize in early meiotic prophase to form the so-called telomere bouquet. In fission yeast, telomeres localize to the nuclear periphery via interaction of the telomeric protein Rap1 with the mem...

    Authors: Hanna Amelina, Shaan Subramaniam, Vera Moiseeva, Christine Anne Armstrong, Siân Rosanna Pearson and Kazunori Tomita

    Citation: BMC Biology 2015 13:37

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  19. Content type: Research article

    Alternative splicing is primarily controlled by the activity of splicing factors and by the elongation of the RNA polymerase II (RNAPII). Recent experiments have suggested a new complex network of splicing reg...

    Authors: Eneritz Agirre, Nicolás Bellora, Mariano Alló, Amadís Pagès, Paola Bertucci, Alberto R Kornblihtt and Eduardo Eyras

    Citation: BMC Biology 2015 13:31

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  20. Content type: Research article

    Photoreceptor degeneration is a main hallmark of many blinding diseases making protection of photoreceptors crucial to prevent vision loss. Thus, regulation of endogenous neuroprotective factors may be key for...

    Authors: Cavit Agca, Karsten Boldt, Andrea Gubler, Isabelle Meneau, Armelle Corpet, Marijana Samardzija, Manuel Stucki, Marius Ueffing and Christian Grimm

    Citation: BMC Biology 2015 13:30

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  21. Content type: Research article

    The digestive systems of animals can become highly specialized in response to their exploration and occupation of new ecological niches. Although studies on different animals have revealed commonalities in gut...

    Authors: José M Martín-Durán and Andreas Hejnol

    Citation: BMC Biology 2015 13:29

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  22. Content type: Research article

    Jasmonates are well known plant signaling components required for stress responses and development. A prominent feature of jasmonate biosynthesis or signaling mutants is the loss of fertility. In contrast to t...

    Authors: Susanne Dobritzsch, Martin Weyhe, Ramona Schubert, Julian Dindas, Gerd Hause, Joachim Kopka and Bettina Hause

    Citation: BMC Biology 2015 13:28

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  23. Content type: Research article

    Collectin-K1 (CL-K1, or CL-11) is a multifunctional Ca2+-dependent lectin with roles in innate immunity, apoptosis and embryogenesis. It binds to carbohydrates on pathogens to activate the lectin pathway of compl...

    Authors: Umakhanth Venkatraman Girija, Christopher M Furze, Alexandre R Gingras, Takayuki Yoshizaki, Katsuki Ohtani, Jamie E Marshall, A Katrine Wallis, Wilhelm J Schwaeble, Mohammed El-Mezgueldi, Daniel A Mitchell, Peter CE Moody, Nobutaka Wakamiya and Russell Wallis

    Citation: BMC Biology 2015 13:27

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  24. Content type: Research article

    Recent genome-wide association studies have uncovered genomic loci that underlie an increased risk for atrial fibrillation, the major cardiac arrhythmia in humans. The most significant locus is located in a ge...

    Authors: Luis A Aguirre, M Eva Alonso, Claudio Badía-Careaga, Isabel Rollán, Cristina Arias, Ana Fernández-Miñán, Elena López-Jiménez, Amelia Aránega, José Luis Gómez-Skarmeta, Diego Franco and Miguel Manzanares

    Citation: BMC Biology 2015 13:26

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  25. Content type: Research article

    Myc proteins are essential regulators of animal growth during normal development, and their deregulation is one of the main driving factors of human malignancies. They function as transcription factors that (i...

    Authors: Eva K Herter, Maria Stauch, Maria Gallant, Elmar Wolf, Thomas Raabe and Peter Gallant

    Citation: BMC Biology 2015 13:25

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  26. Content type: Research article

    Fixation of beneficial genes in bacteria and archaea (collectively, prokaryotes) is often believed to erase pre-existing genomic diversity through the hitchhiking effect, a phenomenon known as genome-wide sele...

    Authors: Nobuto Takeuchi, Otto X Cordero, Eugene V Koonin and Kunihiko Kaneko

    Citation: BMC Biology 2015 13:20

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  27. Content type: Research article

    β-catenin plays a central role in multiple developmental processes. However, it has been difficult to study its pleiotropic effects, because of the dual capacity of β-catenin to coordinate cadherin-dependent c...

    Authors: Max Hans-Peter Gay, Tomas Valenta, Patrick Herr, Lisette Paratore-Hari, Konrad Basler and Lukas Sommer

    Citation: BMC Biology 2015 13:24

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  28. Content type: Research article

    The pilidium larva is a novel body plan that arose within a single clade in the phylum Nemertea - the Pilidiophora. While the sister clade of the Pilidiophora and the basal nemerteans develop directly, pilidio...

    Authors: Laurel S Hiebert and Svetlana A Maslakova

    Citation: BMC Biology 2015 13:23

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  29. Content type: Research article

    We recently identified a novel protein, Rearranged L-myc fusion (Rlf), that is required for DNA hypomethylation and transcriptional activity at two specific regions of the genome known to be sensitive to epige...

    Authors: Sarah K Harten, Harald Oey, Lauren M Bourke, Vandhana Bharti, Luke Isbel, Lucia Daxinger, Pierre Faou, Neil Robertson, Jacqueline M Matthews and Emma Whitelaw

    Citation: BMC Biology 2015 13:21

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  30. Content type: Research article

    The degree of genetic differentiation among populations experiencing high levels of gene flow is expected to be low for neutral genomic sites, but substantial divergence can occur in sites subject to direction...

    Authors: Baocheng Guo, Jacquelin DeFaveri, Graciela Sotelo, Abhilash Nair and Juha Merilä

    Citation: BMC Biology 2015 13:19

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  31. Content type: Research article

    High-throughput sequencing technologies are lifting major limitations to molecular-based ecological studies of eukaryotic microbial diversity, but analyses of the resulting millions of short sequences remain a...

    Authors: Dominik Forster, Lucie Bittner, Slim Karkar, Micah Dunthorn, Sarah Romac, Stéphane Audic, Philippe Lopez, Thorsten Stoeck and Eric Bapteste

    Citation: BMC Biology 2015 13:16

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  32. Content type: Research article

    Circadian clocks control rhythmic expression of a large number of genes in coordination with the 24 hour day-night cycle. The mechanisms generating circadian rhythms, their amplitude and circadian phase are de...

    Authors: Cigdem Sancar, Gencer Sancar, Nati Ha, François Cesbron and Michael Brunner

    Citation: BMC Biology 2015 13:17

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  33. Content type: Research article

    Sleep is characterized by extended periods of quiescence and reduced responsiveness to sensory stimuli. Animals ranging from insects to mammals adapt to environments with limited food by suppressing sleep and ...

    Authors: Masato Yoshizawa, Beatriz G Robinson, Erik R Duboué, Pavel Masek, James B Jaggard, Kelly E O’Quin, Richard L Borowsky, William R Jeffery and Alex C Keene

    Citation: BMC Biology 2015 13:15

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  34. Content type: Research article

    How tissue and organ sizes are specified is one of the great unsolved mysteries in biology. Experiments and mathematical modeling implicate feedback control of cell lineage progression, but a broad understandi...

    Authors: Gentian Buzi, Arthur D Lander and Mustafa Khammash

    Citation: BMC Biology 2015 13:13

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  35. Content type: Research article

    Macrophages have many functions in development and homeostasis as well as innate immunity. Recent studies in mammals suggest that cells arising in the yolk sac give rise to self-renewing macrophage populations...

    Authors: Valerie Garceau, Adam Balic, Carla Garcia-Morales, Kristin A Sauter, Mike J McGrew, Jacqueline Smith, Lonneke Vervelde, Adrian Sherman, Troy E Fuller, Theodore Oliphant, John A Shelley, Raksha Tiwari, Thomas L Wilson, Cosmin Chintoan-Uta, Dave W Burt, Mark P Stevens…

    Citation: BMC Biology 2015 13:12

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