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  1. Content type: Research article

    Dietary intake of specific non-digestible carbohydrates (including prebiotics) is increasingly seen as a highly effective approach for manipulating the composition and activities of the human gut microbiota to...

    Authors: Wing Sun Faith Chung, Alan W. Walker, Petra Louis, Julian Parkhill, Joan Vermeiren, Douwina Bosscher, Sylvia H. Duncan and Harry J. Flint

    Citation: BMC Biology 2016 14:3

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  2. Content type: Research article

    Phenoloxidase (PO)-catalyzed melanization is a universal defense mechanism of insects against pathogenic and parasitic infections. In mosquitos such as Anopheles gambiae, melanotic encapsulation is a resistance m...

    Authors: Yingxia Hu, Yang Wang, Junpeng Deng and Haobo Jiang

    Citation: BMC Biology 2016 14:2

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  3. Content type: Research article

    An emerging cavefish model, the cyprinid genus Sinocyclocheilus, is endemic to the massive southwestern karst area adjacent to the Qinghai-Tibetan Plateau of China. In order to understand whether orogeny influenc...

    Authors: Junxing Yang, Xiaoli Chen, Jie Bai, Dongming Fang, Ying Qiu, Wansheng Jiang, Hui Yuan, Chao Bian, Jiang Lu, Shiyang He, Xiaofu Pan, Yaolei Zhang, Xiaoai Wang, Xinxin You, Yongsi Wang, Ying Sun…

    Citation: BMC Biology 2016 14:1

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  4. Content type: Research article

    Understanding the evolution of divergent developmental trajectories requires detailed comparisons of embryologies at appropriate levels. Cell lineages, the accurate visualization of cleavage patterns, tissue f...

    Authors: Thomas Stach and Chiara Anselmi

    Citation: BMC Biology 2015 13:113

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  5. Content type: Research article

    Genetic interactions, or non-additive effects between genes, play a crucial role in many cellular processes and disease. Which mechanisms underlie these genetic interactions has hardly been characterized. Unde...

    Authors: Katrin Sameith, Saman Amini, Marian J. A. Groot Koerkamp, Dik van Leenen, Mariel Brok, Nathalie Brabers, Philip Lijnzaad, Sander R. van Hooff, Joris J. Benschop, Tineke L. Lenstra, Eva Apweiler, Sake van Wageningen, Berend Snel, Frank C. P. Holstege and Patrick Kemmeren

    Citation: BMC Biology 2015 13:112

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  6. Content type: Research article

    Insulin sensitivity in skeletal muscle is associated with metabolic flexibility, including a high capacity to increase fatty acid (FA) oxidation in response to increased lipid supply. Lipid overload, however, ...

    Authors: Tom Ashmore, Lee D. Roberts, Andrea J. Morash, Aleksandra O. Kotwica, John Finnerty, James A. West, Steven A. Murfitt, Bernadette O. Fernandez, Cristina Branco, Andrew S. Cowburn, Kieran Clarke, Randall S. Johnson, Martin Feelisch, Julian L. Griffin and Andrew J. Murray

    Citation: BMC Biology 2015 13:110

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  7. Content type: Research article

    SAFB1 is a RNA binding protein implicated in the regulation of multiple cellular processes such as the regulation of transcription, stress response, DNA repair and RNA processing. To gain further insight into ...

    Authors: Caroline Rivers, Jalilah Idris, Helen Scott, Mark Rogers, Youn-Bok Lee, Jessica Gaunt, Leonidas Phylactou, Tomaz Curk, Colin Campbell, Jernej Ule, Michael Norman and James B. Uney

    Citation: BMC Biology 2015 13:111

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  8. Content type: Comment

    Zebrafish are able to regenerate various organs and tissues after damage or amputation. To understand better the genetic controls of this process, the authors of this study investigated the expression of two g...

    Authors: Emma Saxon

    Citation: BMC Biology 2015 13:109

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  9. Content type: Question and Answer

    Karrikins are a family of compounds produced by wildfires that can stimulate the germination of dormant seeds of plants from numerous families. Seed plants could have ‘discovered’ karrikins during fire-prone t...

    Authors: Gavin R. Flematti, Kingsley W Dixon and Steven M. Smith

    Citation: BMC Biology 2015 13:108

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  10. Content type: Methodology article

    Membrane proteins regulate a diversity of physiological processes and are the most successful class of targets in drug discovery. However, the number of targets adequately explored in chemical space and the li...

    Authors: Joshua C. Snyder, Thomas F. Pack, Lauren K. Rochelle, Subhasish K. Chakraborty, Ming Zhang, Andrew W. Eaton, Yushi Bai, Lauren A. Ernst, Larry S. Barak, Alan S. Waggoner and Marc G. Caron

    Citation: BMC Biology 2015 13:107

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  11. Content type: Research article

    The deep-sea hypersaline anoxic basins (DHABs) of the Mediterranean (water depth ~3500 m) are some of the most extreme oceanic habitats known. Brines of DHABs are nearly saturated with salt, leading many to su...

    Authors: Joan M. Bernhard, Colin R. Morrison, Ellen Pape, David J. Beaudoin, M. Antonio Todaro, Maria G. Pachiadaki, Konstantinos Ar. Kormas and Virginia P. Edgcomb

    Citation: BMC Biology 2015 13:105

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  12. Content type: Research article

    The hormonal state during the estrus cycle or pregnancy produces alterations on female olfactory perception that are accompanied by specific maternal behaviors, but it is unclear how sex hormones act on the ol...

    Authors: Livio Oboti, Ximena Ibarra-Soria, Anabel Pérez-Gómez, Andreas Schmid, Martina Pyrski, Nicole Paschek, Sarah Kircher, Darren W. Logan, Trese Leinders-Zufall, Frank Zufall and Pablo Chamero

    Citation: BMC Biology 2015 13:104

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  13. Content type: Research article

    Precise spatiotemporal control of gene expression is essential for the establishment of correct cell numbers and identities during brain development. This process involves epigenetic control mechanisms, such a...

    Authors: Martina Zemke, Kalina Draganova, Annika Klug, Anne Schöler, Luis Zurkirchen, Max Hans-Peter Gay, Phil Cheng, Haruhiko Koseki, Tomas Valenta, Dirk Schübeler, Konrad Basler and Lukas Sommer

    Citation: BMC Biology 2015 13:103

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  14. Content type: Research article

    Population genetics predicts that tight linkage between new and/or pre-existing beneficial and deleterious alleles should decrease the efficiency of natural selection in finite populations. By decoupling benef...

    Authors: Dau Dayal Aggarwal, Eugenia Rashkovetsky, Pawel Michalak, Irit Cohen, Yefim Ronin, Dan Zhou, Gabriel G. Haddad and Abraham B. Korol

    Citation: BMC Biology 2015 13:101

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  15. Content type: Research Article

    Force generation and the material properties of cells and tissues are central to morphogenesis but remain difficult to measure in vivo. Insight is often limited to the ratios of mechanical properties obtained ...

    Authors: Pedro F. Machado, Julia Duque, Jocelyn Étienne, Alfonso Martinez-Arias, Guy B. Blanchard and Nicole Gorfinkiel

    Citation: BMC Biology 2015 13:98

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  16. Content type: Research article

    New Caledonian crows use a range of foraging tools, and are the only non-human species known to craft hooks. Based on a small number of observations, their manufacture of hooked stick tools has previously been...

    Authors: Barbara C. Klump, Shoko Sugasawa, James J. H. St Clair and Christian Rutz

    Citation: BMC Biology 2015 13:97

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  17. Content type: Research article

    During cell-cycle progression, substrates of a single master regulatory enzyme can be modified in a specific order. Here, we used experimental and computational approaches to dissect the quantitative mechanism...

    Authors: Dan Lu, Juliet R. Girard, Weihan Li, Arda Mizrak and David O. Morgan

    Citation: BMC Biology 2015 13:96

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  18. Content type: Research article

    Tissue networks such as the vascular networks of plant and animal organs transport signals and nutrients in most multicellular organisms. The transport function of tissue networks depends on topological featur...

    Authors: Carla Verna, Megan G. Sawchuk, Nguyen Manh Linh and Enrico Scarpella

    Citation: BMC Biology 2015 13:94

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  19. Content type: Research article

    The rapidly growing metagenomic databases provide increasing opportunities for computational discovery of new groups of organisms. Identification of new viruses is particularly straightforward given the compar...

    Authors: Natalya Yutin, Sofiya Shevchenko, Vladimir Kapitonov, Mart Krupovic and Eugene V. Koonin

    Citation: BMC Biology 2015 13:95

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  20. Content type: Methodology article

    Complement is a large protein network in plasma that is crucial for human immune defenses and a major cause of aberrant inflammatory reactions. The C5 convertase is a multi-molecular protease complex that cata...

    Authors: Evelien T. M. Berends, Ronald D. Gorham Jr, Maartje Ruyken, Jasper A. Soppe, Hatice Orhan, Piet C. Aerts, Carla J. C. de Haas, Piet Gros and Suzan H. M. Rooijakkers

    Citation: BMC Biology 2015 13:93

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