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  1. Content type: Research article

    Many pathogens secrete toxins that target key host processes resulting in the activation of immune pathways. The secreted Pseudomonas aeruginosa toxin Exotoxin A (ToxA) disrupts intestinal protein synthesis, whic...

    Authors: Deborah L. McEwan, Rhonda L. Feinbaum, Nicholas Stroustrup, Wilhelm Haas, Annie L. Conery, Anthony Anselmo, Ruslan Sadreyev and Frederick M. Ausubel

    Citation: BMC Biology 2016 14:105

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  2. Content type: Research article

    Defects in genes involved in mitochondrial fatty-acid oxidation (mFAO) reduce the ability of patients to cope with metabolic challenges. mFAO enzymes accept multiple substrates of different chain length, leadi...

    Authors: Karen van Eunen, Catharina M. L. Volker-Touw, Albert Gerding, Aycha Bleeker, Justina C. Wolters, Willemijn J. van Rijt, Anne-Claire M. F. Martines, Klary E. Niezen-Koning, Rebecca M. Heiner, Hjalmar Permentier, Albert K. Groen, Dirk-Jan Reijngoud, Terry G. J. Derks and Barbara M. Bakker

    Citation: BMC Biology 2016 14:107

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  3. Content type: Research article

    Tribbles proteins are conserved pseudokinases that function to control kinase signalling and transcription in diverse biological processes. Abnormal function in human Tribbles has been implicated in a number o...

    Authors: Kyung Won Kim, Nishant Thakur, Christopher A. Piggott, Shizue Omi, Jolanta Polanowska, Yishi Jin and Nathalie Pujol

    Citation: BMC Biology 2016 14:104

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  4. Content type: Research article

    Palmitoylation, the addition of palmitate to proteins by palmitoyl acyltransferases (PATs), is an important regulator of synaptic protein localization and function. Many palmitoylated proteins and PATs have be...

    Authors: Shaun S. Sanders, Matthew P. Parsons, Katherine K. N. Mui, Amber L. Southwell, Sonia Franciosi, Daphne Cheung, Sabine Waltl, Lynn A. Raymond and Michael R. Hayden

    Citation: BMC Biology 2016 14:108

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  5. Content type: Research article

    The specificity of synaptic connections is fundamental for proper neural circuit function. Specific neuronal connections that underlie information processing in the sensory cortex are initially established wit...

    Authors: Etsuko Tarusawa, Makoto Sanbo, Atsushi Okayama, Toshio Miyashita, Takashi Kitsukawa, Teruyoshi Hirayama, Takahiro Hirabayashi, Sonoko Hasegawa, Ryosuke Kaneko, Shunsuke Toyoda, Toshihiro Kobayashi, Megumi Kato-Itoh, Hiromitsu Nakauchi, Masumi Hirabayashi, Takeshi Yagi and Yumiko Yoshimura

    Citation: BMC Biology 2016 14:103

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  6. Content type: Commentary

    Delving into European prehistory, two recent studies analyze ancient DNA from bison species depicted by our ancestors on the walls of their caves. The DNA tells a story of migrations driven by climate change b...

    Authors: Johannes A. Lenstra and Jianquan Liu

    Citation: BMC Biology 2016 14:100

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  7. Content type: Research article

    The several-micrometer-sized Toxoplasma gondii protozoan parasite invades virtually any type of nucleated cell from a warm-blooded animal within seconds. Toxoplasma initiates the formation of a tight ring-like ju...

    Authors: Marion Bichet, Bastien Touquet, Virginie Gonzalez, Isabelle Florent, Markus Meissner and Isabelle Tardieux

    Citation: BMC Biology 2016 14:97

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  8. Content type: Research article

    Arbovirus transmission by the mosquito Aedes aegypti can be reduced by the introduction and establishment of the endosymbiotic bacteria Wolbachia in wild populations of the vector. Wolbachia spreads by increasing...

    Authors: Penelope A. Hancock, Vanessa L. White, Scott A. Ritchie, Ary A. Hoffmann and H. Charles J. Godfray

    Citation: BMC Biology 2016 14:96

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  9. Content type: Research article

    TPA Induced Sequence 7 acts as a transcriptional co-regulator controlling the expression of genes involved in differentiation of various cell types, including skeletal myoblasts. We and others have shown that ...

    Authors: Andrea Lammirato, Katherin Patsch, Fabien Feiereisen, Karl Maly, Charity Nofziger, Markus Paulmichl, Hubert Hackl, Zlatko Trajanoski, Taras Valovka, Lukas A. Huber and Ilja Vietor

    Citation: BMC Biology 2016 14:95

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  10. Content type: Research article

    Climatic and environmental fluctuations as well as anthropogenic pressure have led to the extinction of much of Europe’s megafauna. The European bison or wisent (Bison bonasus), one of the last wild European larg...

    Authors: Diyendo Massilani, Silvia Guimaraes, Jean-Philip Brugal, E. Andrew Bennett, Malgorzata Tokarska, Rose-Marie Arbogast, Gennady Baryshnikov, Gennady Boeskorov, Jean-Christophe Castel, Sergey Davydov, Stéphane Madelaine, Olivier Putelat, Natalia N. Spasskaya, Hans-Peter Uerpmann, Thierry Grange and Eva-Maria Geigl

    Citation: BMC Biology 2016 14:93

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  11. Content type: Research article

    Relapsed acute lymphoblastic leukemia (ALL) is one of the main causes of mortality in childhood malignancies. Previous genetic studies demonstrated that chemoresistant ALL is driven by activating mutations in NT5...

    Authors: Aleš Hnízda, Jana Škerlová, Milan Fábry, Petr Pachl, Martina Šinalová, Lukáš Vrzal, Petr Man, Petr Novák, Pavlína Řezáčová and Václav Veverka

    Citation: BMC Biology 2016 14:91

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  12. Content type: Comment

    A common symbiont of insects, the bacterium Wolbachia has been implicated in phenomena as diverse as sex determination, pathogen defence and speciation and is being used in public health programs to prevent mosqu...

    Authors: Francis M. Jiggins

    Citation: BMC Biology 2016 14:92

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  13. Content type: Research article

    The red flour beetle Tribolium castaneum is an emerging insect model organism representing the largest insect order, Coleoptera, which encompasses several serious agricultural and forest pests. Despite the ecolog...

    Authors: Stefan Dippel, Martin Kollmann, Georg Oberhofer, Alice Montino, Carolin Knoll, Milosz Krala, Karl-Heinz Rexer, Sergius Frank, Robert Kumpf, Joachim Schachtner and Ernst A. Wimmer

    Citation: BMC Biology 2016 14:90

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  14. Content type: Research article

    The navigation of magnetotactic bacteria relies on specific intracellular organelles, the magnetosomes, which are membrane-enclosed crystals of magnetite aligned into a linear chain. The magnetosome chain acts...

    Authors: Mauricio Toro-Nahuelpan, Frank D. Müller, Stefan Klumpp, Jürgen M. Plitzko, Marc Bramkamp and Dirk Schüler

    Citation: BMC Biology 2016 14:88

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  15. Content type: Research article

    The General Control Nonderepressible 2 (GCN2) kinase is a conserved member of the integrated stress response (ISR) pathway that represses protein translation and helps cells to adapt to conditions of nutrient ...

    Authors: Rafael C. Ferraz, Henrique Camara, Evandro A. De-Souza, Silas Pinto, Ana Paula F. Pinca, Richard C. Silva, Vitor N. Sato, Beatriz A. Castilho and Marcelo A. Mori

    Citation: BMC Biology 2016 14:87

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  16. Content type: Research article

    Application of apomixis, or asexual seed formation, in crop breeding would allow rapid fixation of complex traits, economizing improved crop delivery. Identification of apomixis genes is confounded by the poly...

    Authors: David S. Rabiger, Jennifer M. Taylor, Andrew Spriggs, Melanie L. Hand, Steven T. Henderson, Susan D. Johnson, Karsten Oelkers, Maria Hrmova, Keisuke Saito, Go Suzuki, Yasuhiko Mukai, Bernard J. Carroll and Anna M. G. Koltunow

    Citation: BMC Biology 2016 14:86

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  17. Content type: Comment

    Any figure in a research article will typically represent only a small portion of the total data gained by a researcher for that experiment, and it is therefore key that the figure accurately reflects what was...

    Authors: John F. Y. Brookfield

    Citation: BMC Biology 2016 14:85

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  18. Content type: Research article

    In February 2016, a new fungal disease was spotted in wheat fields across eight districts in Bangladesh. The epidemic spread to an estimated 15,000 hectares, about 16 % of the cultivated wheat area in Banglade...

    Authors: M. Tofazzal Islam, Daniel Croll, Pierre Gladieux, Darren M. Soanes, Antoine Persoons, Pallab Bhattacharjee, Md. Shaid Hossain, Dipali Rani Gupta, Md. Mahbubur Rahman, M. Golam Mahboob, Nicola Cook, Moin U. Salam, Musrat Zahan Surovy, Vanessa Bueno Sancho, João Leodato Nunes Maciel, Antonio NhaniJúnior…

    Citation: BMC Biology 2016 14:84

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  19. Content type: Research article

    Like most animals, insects rely on their olfactory systems for finding food and mates and in avoiding noxious chemicals and predators. Most insect olfactory neurons express an odorant-specific odorant receptor...

    Authors: Suhyoung Bahk and Walton D. Jones

    Citation: BMC Biology 2016 14:83

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