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  1. Content type: Research article

    Regenerating damaged tissue is a complex process, requiring progenitor cells that must be stimulated to undergo proliferation, differentiation and, often, migratory behaviors and morphological changes. Multipl...

    Authors: Mario Sánchez, Maria Laura Ceci, Daniela Gutiérrez, Consuelo Anguita-Salinas and Miguel L. Allende

    Citation: BMC Biology 2016 14:27

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  2. Content type: Comment

    The authors of this paper were interested to see whether the expression of three proteins (A, B and C) was altered in a knockout mouse model of a gene encoding Protein X. Each experiment measured the expressio...

    Authors: Graham Bell

    Citation: BMC Biology 2016 14:28

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  3. Content type: Research article

    G-protein-coupled receptors (GPCRs), in the form of monomers or homodimers that bind heterotrimeric G proteins, are fundamental in the transfer of extracellular stimuli to intracellular signaling pathways. Dif...

    Authors: Gemma Navarro, Arnau Cordomí, Monika Zelman-Femiak, Marc Brugarolas, Estefania Moreno, David Aguinaga, Laura Perez-Benito, Antoni Cortés, Vicent Casadó, Josefa Mallol, Enric I. Canela, Carme Lluís, Leonardo Pardo, Ana J. García-Sáez, Peter J. McCormick and Rafael Franco

    Citation: BMC Biology 2016 14:26

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  4. Content type: Research article

    A crucial event in the differentiation of mouse embryonic stem cells (ESCs) is the exit from the pluripotent ground state that leads to the acquisition of the ‘primed’ pluripotent phenotype, characteristic of ...

    Authors: Angelica Navarra, Anna Musto, Anna Gargiulo, Giuseppe Petrosino, Giovanna Maria Pierantoni, Alfredo Fusco, Tommaso Russo and Silvia Parisi

    Citation: BMC Biology 2016 14:24

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  5. Content type: Research article

    Synaptic loss strongly correlates with memory deterioration. Local accumulation of amyloid β (Aβ) peptide, and neurotoxic Aβ42 in particular, due to abnormal neuronal activity may underlie synaptic dysfunction...

    Authors: Akira Kuzuya, Katarzyna M. Zoltowska, Kathryn L. Post, Muriel Arimon, Xuejing Li, Sarah Svirsky, Masato Maesako, Alona Muzikansky, Vivek Gautam, Dora Kovacs, Bradley T. Hyman and Oksana Berezovska

    Citation: BMC Biology 2016 14:25

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  6. Content type: Research article

    The dorsal midline region of the neural tube that results from closure of the neural folds is generally termed the roof plate (RP). However, this domain is highly dynamic and complex, and is first transiently ...

    Authors: Erez Nitzan, Oshri Avraham, Nitza Kahane, Shai Ofek, Deepak Kumar and Chaya Kalcheim

    Citation: BMC Biology 2016 14:23

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  7. Content type: Review

    In his splendid article “Can a biologist fix a radio? — or, what I learned while studying apoptosis,” Y. Lazebnik argues that when one uses the right tools, similarity between a biological system, like a signa...

    Authors: Mustafa Khammash

    Citation: BMC Biology 2016 14:22

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  8. Content type: Research article

    Resident fibroblasts synthesize the cardiac extracellular matrix, and can undergo phenotype conversion to myofibroblasts to augment matrix production, impairing function and contributing to organ failure. A si...

    Authors: Rushita A. Bagchi, Patricia Roche, Nina Aroutiounova, Leon Espira, Bernard Abrenica, Ronen Schweitzer and Michael P. Czubryt

    Citation: BMC Biology 2016 14:21

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  9. Content type: Research article

    Self-renewing, chemoresistant breast cancer stem cells are believed to contribute significantly to cancer invasion, migration and patient relapse. Therefore, the identification of signaling pathways that regul...

    Authors: Elizabeth A. Stanford, Zhongyan Wang, Olga Novikov, Francesca Mulas, Esther Landesman-Bollag, Stefano Monti, Brenden W. Smith, David C. Seldin, George J. Murphy and David H. Sherr

    Citation: BMC Biology 2016 14:20

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  10. Content type: Research article

    Epithelial-mesenchymal cross talk is centerpiece in the development of many branched organs, including the lungs. The embryonic lung mesoderm provides instructional information not only for lung architectural ...

    Authors: Aimin Li, Shudong Ma, Susan M. Smith, Matt K. Lee, Ashley Fischer, Zea Borok, Saverio Bellusci, Changgong Li and Parviz Minoo

    Citation: BMC Biology 2016 14:19

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  11. Content type: Research article

    Understanding how embryos specify asymmetric axes is a major focus of biology. While much has been done to discover signaling pathways and transcription factors important for axis specification, comparatively ...

    Authors: Zhijun Qiu, Zeinab Elsayed, Veronica Peterkin, Suehyb Alkatib, Dorothy Bennett and Joseph W. Landry

    Citation: BMC Biology 2016 14:18

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  12. Content type: Commentary

    Because of their sessile lifestyle and the lack of the sensory and feeding structures usually associated with the cephalic end, fixing the antero-posterior (AP) polarity of tapeworms is somewhat equivocal and ...

    Authors: Alessandro Minelli

    Citation: BMC Biology 2016 14:17

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  13. Content type: Research article

    Early developmental patterns of flatworms are extremely diverse and difficult to compare between distant groups. In parasitic flatworms, such as tapeworms, this is confounded by highly derived life cycles invo...

    Authors: Uriel Koziol, Francesca Jarero, Peter D. Olson and Klaus Brehm

    Citation: BMC Biology 2016 14:10

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  14. Content type: Research article

    In eukaryotes, tRNA trafficking between the nucleus and cytoplasm is a complex process connected with cell cycle regulation. Such trafficking is therefore of fundamental importance in cell biology, and disrupt...

    Authors: Dian-Fu Chen, Cheng Lin, Hong-Liang Wang, Li Zhang, Li Dai, Sheng-Nan Jia, Rong Zhou, Ran Li, Jin-Shu Yang, Fan Yang, James S. Clegg, Hiromichi Nagasawa and Wei-Jun Yang

    Citation: BMC Biology 2016 14:16

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  15. Content type: Research article

    Adaptation of the cellular metabolism to varying external conditions is brought about by regulated changes in the activity of enzymes and transporters. Hormone-dependent reversible enzyme phosphorylation and c...

    Authors: Sascha Bulik, Hermann-Georg Holzhütter and Nikolaus Berndt

    Citation: BMC Biology 2016 14:15

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  16. Content type: Research article

    The immunity-related GTPases (IRGs) constitute a powerful cell-autonomous resistance system against several intracellular pathogens. Irga6 is a dynamin-like protein that oligomerizes at the parasitophorous vac...

    Authors: Kathrin Schulte, Nikolaus Pawlowski, Katja Faelber, Chris Fröhlich, Jonathan Howard and Oliver Daumke

    Citation: BMC Biology 2016 14:14

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  17. Content type: Research article

    Plants deploy immune receptors to detect pathogen-derived molecules and initiate defense responses. Intracellular plant immune receptors called nucleotide-binding leucine-rich repeat (NLR) proteins contain a c...

    Authors: Panagiotis F. Sarris, Volkan Cevik, Gulay Dagdas, Jonathan D. G. Jones and Ksenia V. Krasileva

    Citation: BMC Biology 2016 14:8

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  18. Content type: Research article

    Olfaction is a fundamental sense through which most animals perceive the external world. The olfactory system detects odors via specialized sensory organs such as the main olfactory epithelium and the vomerona...

    Authors: Thiago S. Nakahara, Leonardo M. Cardozo, Ximena Ibarra-Soria, Andrew D. Bard, Vinicius M. A. Carvalho, Guilherme Z. Trintinalia, Darren W. Logan and Fabio Papes

    Citation: BMC Biology 2016 14:12

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  19. Content type: Research article

    Fast responses can provide a competitive advantage when resources are inhomogeneously distributed. The nematode Caenorhabditis elegans was shown to modulate locomotion on a lawn of bacterial food in serotonin (5-...

    Authors: Shachar Iwanir, Adam S. Brown, Stanislav Nagy, Dana Najjar, Alexander Kazakov, Kyung Suk Lee, Alon Zaslaver, Erel Levine and David Biron

    Citation: BMC Biology 2016 14:9

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  20. Content type: Research article

    Most mammalian genes display alternative cleavage and polyadenylation (APA). Previous studies have indicated preferential expression of APA isoforms with short 3’ untranslated regions (3’UTRs) in testes.

    Authors: Wencheng Li, Ji Yeon Park, Dinghai Zheng, Mainul Hoque, Ghassan Yehia and Bin Tian

    Citation: BMC Biology 2016 14:6

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  21. Content type: Research article

    Tankyrases are poly(adenosine diphosphate)-ribose polymerases that contribute to biological processes as diverse as modulation of Wnt signaling, telomere maintenance, vesicle trafficking, and microtubule-depen...

    Authors: Barbara Lupo, Jorge Vialard, Francesco Sassi, Patrick Angibaud, Alberto Puliafito, Emanuela Pupo, Letizia Lanzetti, Paolo M. Comoglio, Andrea Bertotti and Livio Trusolino

    Citation: BMC Biology 2016 14:5

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  22. Content type: Comment

    Male crickets (Gryllus bimaculatus) establish dominance hierarchies within a population by fighting with one another. Larger males win fights more frequently than their smaller counterparts, and a previous study ...

    Authors: Emma Saxon

    Citation: BMC Biology 2016 14:4

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