Figure 2

MST1 kinase is dramatically increased during denervation-induced atrophy in fast-dominant muscles from adult mice. A. Quantitative PCR showed mRNA of MST1 was continuously increased three and seven days after denervation. B and C. Western blotting and densitometry showed MST1 and MST2 protein levels were both increased during the process of denervation-induced atrophy in TA muscle. D and E. Seven days after denervation, MST1 protein levels were dramatically increased in multiple fast-dominant muscles (TA, Gas and EDL), but not in slow-dominant soleus and FDB muscles. *P < 0.05 by two-tailed Student's test.