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  1. Research article

    Long-term microfluidic tracking of coccoid cyanobacterial cells reveals robust control of division timing

    Cyanobacteria are important agents in global carbon and nitrogen cycling and hold great promise for biotechnological applications. Model organisms such as Synechocystis sp. and Synechococcus sp. have advanced our...

    Feiqiao Brian Yu, Lisa Willis, Rosanna Man Wah Chau, Alessandro Zambon, Mark Horowitz, Devaki Bhaya, Kerwyn Casey Huang and Stephen R. Quake

    BMC Biology 2017 15:11

    Published on: 14 February 2017

  2. Research article

    How flies are flirting on the fly

    Flies have some of the most elaborate visual systems in the Insecta, often featuring large, sexually dimorphic eyes with specialized “bright zones” that may have a functional role during mate-seeking behavior....

    Courtney Eichorn, Michael Hrabar, Emma C. Van Ryn, Bekka S. Brodie, Adam J. Blake and Gerhard Gries

    BMC Biology 2017 15:2

    Published on: 14 February 2017

  3. Research article

    Enhancing circadian clock function in cancer cells inhibits tumor growth

    Circadian clocks control cell cycle factors, and circadian disruption promotes cancer. To address whether enhancing circadian rhythmicity in tumor cells affects cell cycle progression and reduces proliferation...

    Silke Kiessling, Lou Beaulieu-Laroche, Ian D. Blum, Dominic Landgraf, David K. Welsh, Kai-Florian Storch, Nathalie Labrecque and Nicolas Cermakian

    BMC Biology 2017 15:13

    Published on: 14 February 2017

  4. Research article

    MicroRNA miR-29 controls a compensatory response to limit neuronal iron accumulation during adult life and aging

    A widespread modulation of gene expression occurs in the aging brain, but little is known as to the upstream drivers of these changes. MicroRNAs emerged as fine regulators of gene expression in many biological...

    Roberto Ripa, Luca Dolfi, Marco Terrigno, Luca Pandolfini, Aurora Savino, Valeria Arcucci, Marco Groth, Eva Terzibasi Tozzini, Mario Baumgart and Alessandro Cellerino

    BMC Biology 2017 15:9

    Published on: 13 February 2017

  5. Research article

    Phosphorylation-dependent regulation of ALDH1A1 by Aurora kinase A: insights on their synergistic relationship in pancreatic cancer

    Epithelial-to-mesenchymal transition (EMT) and cancer stem cell (CSC) formation are key underlying causes that promote extensive metastasis, drug resistance, and tumor recurrence in highly lethal pancreatic ca...

    Jing Wang, Kumar Nikhil, Keith Viccaro, Lei Chang, Jacoba White and Kavita Shah

    BMC Biology 2017 15:10

    Published on: 13 February 2017

  6. Research article

    Nuclear genetic codes with a different meaning of the UAG and the UAA codon

    Departures from the standard genetic code in eukaryotic nuclear genomes are known for only a handful of lineages and only a few genetic code variants seem to exist outside the ciliates, the most creative group...

    Tomáš Pánek, David Žihala, Martin Sokol, Romain Derelle, Vladimír Klimeš, Miluše Hradilová, Eliška Zadrobílková, Edward Susko, Andrew J. Roger, Ivan Čepička and Marek Eliáš

    BMC Biology 2017 15:8

    Published on: 13 February 2017

  7. Research article

    Amyloid-like aggregation of provasopressin in diabetes insipidus and secretory granule sorting

    Aggregation of peptide hormone precursors in the trans-Golgi network is an essential process in the biogenesis of secretory granules in endocrine cells. It has recently been proposed that this aggregation corr...

    Nicole Beuret, Franziska Hasler, Cristina Prescianotto-Baschong, Julia Birk, Jonas Rutishauser and Martin Spiess

    BMC Biology 2017 15:5

    Published on: 26 January 2017

  8. Research article

    Surface attachment, promoted by the actomyosin system of Toxoplasma gondii is important for efficient gliding motility and invasion

    Apicomplexan parasites employ a unique form of movement, termed gliding motility, in order to invade the host cell. This movement depends on the parasite’s actomyosin system, which is thought to generate the f...

    Jamie A. Whitelaw, Fernanda Latorre-Barragan, Simon Gras, Gurman S. Pall, Jacqueline M. Leung, Aoife Heaslip, Saskia Egarter, Nicole Andenmatten, Shane R. Nelson, David M. Warshaw, Gary E. Ward and Markus Meissner

    BMC Biology 2017 15:1

    Published on: 18 January 2017

  9. Research article

    Frequency of influenza H3N2 intra-subtype reassortment: attributes and implications of reassortant spread

    Increasing evidence suggests that influenza reassortment not only contributes to the emergence of new human pandemics but also plays an important role in seasonal influenza epidemics, disease severity, evoluti...

    Irina Maljkovic Berry, Melanie C. Melendrez, Tao Li, Anthony W. Hawksworth, Gary T. Brice, Patrick J. Blair, Eric S. Halsey, Maya Williams, Stefan Fernandez, In-Kyu Yoon, Leslie D. Edwards, Robert Kuschner, Xiaoxu Lin, Stephen J. Thomas and Richard G. Jarman

    BMC Biology 2016 14:117

    Published on: 29 December 2016

  10. Comment

    Quantifying western blots: none more black

    Western blotting is among the most common techniques used in molecular biology and a simple way of assessing the presence or absence of a protein. It is also commonly used to compare protein levels in differen...

    Graham Bell

    BMC Biology 2016 14:116

    Published on: 28 December 2016

  11. Question and Answer

    Q&A: what are brassinosteroids and how do they act in plants?

    Brassinosteroids (BRs) are a class of polyhydroxylated steroidal phytohormones in plants with similar structures to animals’ steroid hormones. Brassinosteroids regulate a wide range of physiological processes ...

    Jiao Tang, Zhifu Han and Jijie Chai

    BMC Biology 2016 14:113

    Published on: 22 December 2016

  12. Research article

    The draft genome of whitefly Bemisia tabaci MEAM1, a global crop pest, provides novel insights into virus transmission, host adaptation, and insecticide resistance

    The whitefly Bemisia tabaci (Hemiptera: Aleyrodidae) is among the 100 worst invasive species in the world. As one of the most important crop pests and virus vectors, B. tabaci causes substantial crop losses and p...

    Wenbo Chen, Daniel K. Hasegawa, Navneet Kaur, Adi Kliot, Patricia Valle Pinheiro, Junbo Luan, Marcus C. Stensmyr, Yi Zheng, Wenli Liu, Honghe Sun, Yimin Xu, Yuan Luo, Angela Kruse, Xiaowei Yang, Svetlana Kontsedalov, Galina Lebedev…

    BMC Biology 2016 14:110

    Published on: 14 December 2016

  13. Research article

    Functional characterisation of long intergenic non-coding RNAs through genetic interaction profiling in Saccharomyces cerevisiae

    Transcriptome studies have revealed that many eukaryotic genomes are pervasively transcribed producing numerous long non-coding RNAs (lncRNAs). However, only a few lncRNAs have been ascribed a cellular role th...

    Dimitris Kyriakou, Emmanouil Stavrou, Panayiota Demosthenous, Georgia Angelidou, Bryan-Joseph San Luis, Charles Boone, Vasilis J. Promponas and Antonis Kirmizis

    BMC Biology 2016 14:106

    Published on: 7 December 2016

  14. Research article

    The topology, structure and PE interaction of LITAF underpin a Charcot-Marie-Tooth disease type 1C

    Mutations in Lipopolysaccharide-induced tumour necrosis factor-α factor (LITAF) cause the autosomal dominant inherited peripheral neuropathy, Charcot-Marie-Tooth disease type 1C (CMT1C). LITAF encodes a 17 kDa pr...

    Anita K. Ho, Jane L. Wagstaff, Paul T. Manna, Lena Wartosch, Seema Qamar, Elspeth F. Garman, Stefan M. V. Freund and Rhys C. Roberts

    BMC Biology 2016 14:109

    Published on: 7 December 2016

  15. Research article

    Sudden death due to paralysis and synaptic and behavioral deficits when Hip14/Zdhhc17 is deleted in adult mice

    Palmitoylation, the addition of palmitate to proteins by palmitoyl acyltransferases (PATs), is an important regulator of synaptic protein localization and function. Many palmitoylated proteins and PATs have be...

    Shaun S. Sanders, Matthew P. Parsons, Katherine K. N. Mui, Amber L. Southwell, Sonia Franciosi, Daphne Cheung, Sabine Waltl, Lynn A. Raymond and Michael R. Hayden

    BMC Biology 2016 14:108

    Published on: 7 December 2016

  16. Research article

    Coordinated inhibition of C/EBP by Tribbles in multiple tissues is essential for Caenorhabditis elegans development

    Tribbles proteins are conserved pseudokinases that function to control kinase signalling and transcription in diverse biological processes. Abnormal function in human Tribbles has been implicated in a number o...

    Kyung Won Kim, Nishant Thakur, Christopher A. Piggott, Shizue Omi, Jolanta Polanowska, Yishi Jin and Nathalie Pujol

    BMC Biology 2016 14:104

    Published on: 7 December 2016

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