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  1. Question and Answer

    Q&A: Expansion microscopy

    Expansion microscopy (ExM) is a recently invented technology that uses swellable charged polymers, synthesized densely and with appropriate topology throughout a preserved biological specimen, to physically ma...

    Ruixuan Gao, Shoh M. Asano and Edward S. Boyden

    BMC Biology 2017 15:50

    Published on: 19 June 2017

  2. Editorial

    Who needs registered reports?

    Registered Reports, an article format initiated to help promote transparency and reproducibility in the preclinical and social sciences, are spreading into the biological literature. The format is now offered by

    Miranda Robertson

    BMC Biology 2017 15:49

    Published on: 15 June 2017

  3. Research article

    Matriptase zymogen supports epithelial development, homeostasis and regeneration

    Matriptase is a membrane serine protease essential for epithelial development, homeostasis, and regeneration, as well as a central orchestrator of pathogenic pericellular signaling in the context of inflammato...

    Stine Friis, Daniel Tadeo, Sylvain M. Le-Gall, Henrik Jessen Jürgensen, Katiuchia Uzzun Sales, Eric Camerer and Thomas H. Bugge

    BMC Biology 2017 15:46

    Published on: 1 June 2017

  4. Methodology article

    Cell fixation and preservation for droplet-based single-cell transcriptomics

    Recent developments in droplet-based microfluidics allow the transcriptional profiling of thousands of individual cells in a quantitative, highly parallel and cost-effective way. A critical, often limiting ste...

    Jonathan Alles, Nikos Karaiskos, Samantha D. Praktiknjo, Stefanie Grosswendt, Philipp Wahle, Pierre-Louis Ruffault, Salah Ayoub, Luisa Schreyer, Anastasiya Boltengagen, Carmen Birchmeier, Robert Zinzen, Christine Kocks and Nikolaus Rajewsky

    BMC Biology 2017 15:44

    Published on: 19 May 2017

  5. Methodology article

    Differential DARC/ACKR1 expression distinguishes venular from non-venular endothelial cells in murine tissues

    Intravascular leukocyte recruitment in most vertebrate tissues is restricted to postcapillary and collecting venules, whereas capillaries and arterioles usually support little or no leukocyte adhesion. This se...

    Aude Thiriot, Carolina Perdomo, Guiying Cheng, Igor Novitzky-Basso, Sara McArdle, Jamie K. Kishimoto, Olga Barreiro, Irina Mazo, Robinson Triboulet, Klaus Ley, Antal Rot and Ulrich H. von Andrian

    BMC Biology 2017 15:45

    Published on: 19 May 2017

  6. Commentary

    Knowing where the nose is

    Improvements in imaging technology and the development of powerful machine learning algorithms are revolutionizing the study of animal behavior in the laboratory. These innovations promise to reveal both globa...

    Winthrop F. Gillis and Sandeep R. Datta

    BMC Biology 2017 15:42

    Published on: 15 May 2017

  7. Research article

    Optogenetic interrogation reveals separable G-protein-dependent and -independent signalling linking G-protein-coupled receptors to the circadian oscillator

    Endogenous circadian oscillators distributed across the mammalian body are synchronised among themselves and with external time via a variety of signalling molecules, some of which interact with G-protein-coup...

    Helena J. Bailes, Nina Milosavljevic, Ling-Yu Zhuang, Elliot J. Gerrard, Tomoki Nishiguchi, Takeaki Ozawa and Robert J. Lucas

    BMC Biology 2017 15:40

    Published on: 15 May 2017

  8. Research article

    Time-resolved dual transcriptomics reveal early induced Nicotiana benthamiana root genes and conserved infection-promoting Phytophthora palmivora effectors

    Plant-pathogenic oomycetes are responsible for economically important losses in crops worldwide. Phytophthora palmivora, a tropical relative of the potato late blight pathogen, causes rotting diseases in many tro...

    Edouard Evangelisti, Anna Gogleva, Thomas Hainaux, Mehdi Doumane, Frej Tulin, Clément Quan, Temur Yunusov, Kévin Floch and Sebastian Schornack

    BMC Biology 2017 15:39

    Published on: 11 May 2017

  9. Research article

    Heterosis as a consequence of regulatory incompatibility

    The merging of genomes in inter-specific hybrids can result in novel phenotypes, including increased growth rate and biomass yield, a phenomenon known as heterosis. Heterosis is typically viewed as the opposit...

    Rebecca H. Herbst, Dana Bar-Zvi, Sharon Reikhav, Ilya Soifer, Michal Breker, Ghil Jona, Eyal Shimoni, Maya Schuldiner, Avraham A. Levy and Naama Barkai

    BMC Biology 2017 15:38

    Published on: 11 May 2017

  10. Comment

    Can a biologist fix a smartphone?—Just hack it!

    Biological systems integrate multiscale processes and networks and are, therefore, viewed as difficult to dissect. However, because of the clear-cut separation between the software code (the information encode...

    Sophien Kamoun

    BMC Biology 2017 15:37

    Published on: 8 May 2017

  11. Research article

    Central peptidergic modulation of peripheral olfactory responses

    Animal olfactory systems detect volatile environmental chemicals and integrate this information to direct the discovery of food and mates as well as danger avoidance. Rather than remaining constant, olfactory ...

    Sion Lee, Young-Joon Kim and Walton D. Jones

    BMC Biology 2017 15:35

    Published on: 5 May 2017

  12. Review

    The biological function of the cellular prion protein: an update

    The misfolding of the cellular prion protein (PrPC) causes fatal neurodegenerative diseases. Yet PrPC is highly conserved in mammals, suggesting that it exerts beneficial functions preventing its evolutionary eli...

    Marie-Angela Wulf, Assunta Senatore and Adriano Aguzzi

    BMC Biology 2017 15:34

    Published on: 2 May 2017

  13. Research article

    Ion- and water-binding sites inside an occluded hourglass pore of a trimeric intracellular cation (TRIC) channel

    Trimeric intracellular cation (TRIC) channels are crucial for Ca2+ handling in eukaryotes and are involved in K+ uptake in prokaryotes. Recent studies on the representative members of eukaryotic and prokaryotic T...

    Xiaomin Ou, Jianli Guo, Longfei Wang, Hanting Yang, Xiuying Liu, Jianyuan Sun and Zhenfeng Liu

    BMC Biology 2017 15:31

    Published on: 22 April 2017

  14. Research article

    Single swim sessions in C. elegans induce key features of mammalian exercise

    Exercise exerts remarkably powerful effects on metabolism and health, with anti-disease and anti-aging outcomes. Pharmacological manipulation of exercise benefit circuits might improve the health of the sedent...

    Ricardo Laranjeiro, Girish Harinath, Daniel Burke, Bart P. Braeckman and Monica Driscoll

    BMC Biology 2017 15:30

    Published on: 10 April 2017

  15. Research article

    OsLG3 contributing to rice grain length and yield was mined by Ho-LAMap

    Most agronomic traits in rice are complex and polygenic. The identification of quantitative trait loci (QTL) for grain length is an important objective of rice genetic research and breeding programs.

    Jianping Yu, Haiyan Xiong, Xiaoyang Zhu, Hongliang Zhang, Huihui Li, Jinli Miao, Wensheng Wang, Zuoshun Tang, Zhanying Zhang, Guoxin Yao, Qiang Zhang, Yinghua Pan, Xin Wang, M. A. R. Rashid, Jinjie Li, Yongming Gao…

    BMC Biology 2017 15:28

    Published on: 6 April 2017

  16. Methodology article

    A multi-animal tracker for studying complex behaviors

    Animals exhibit astonishingly complex behaviors. Studying the subtle features of these behaviors requires quantitative, high-throughput, and accurate systems that can cope with the often rich perplexing data.

    Eyal Itskovits, Amir Levine, Ehud Cohen and Alon Zaslaver

    BMC Biology 2017 15:29

    Published on: 6 April 2017

  17. Research article

    Giardia intestinalis mitosomes undergo synchronized fission but not fusion and are constitutively associated with the endoplasmic reticulum

    Mitochondria of opisthokonts undergo permanent fission and fusion throughout the cell cycle. Here, we investigated the dynamics of the mitosomes, the simplest forms of mitochondria, in the anaerobic protist pa...

    Luboš Voleman, Vladimíra Najdrová, Ásgeir Ástvaldsson, Pavla Tůmová, Elin Einarsson, Zdeněk Švindrych, Guy M. Hagen, Jan Tachezy, Staffan G. Svärd and Pavel Doležal

    BMC Biology 2017 15:27

    Published on: 3 April 2017

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