Table 1 Enrichment (based on DNA-array data) of gene classes ^a

Gene group	Gene class	Group size	Isolation site		Polymorphic by ratio
Gene group	Gene class	Group size	Overlap	Significance^b	Overlap	Significance
Serpentine receptors
Superfamily Str	srh	289	118	20.3^c	40	0.0
	str	219	68	6.4^c	39	0.2
	sri	76	28	4.7^c	12	0.1
	srj	45	19	4.5^c	7	0.2
Solo	srz	104	43	8.4^c	27	1.4
	srw	145	53	7.8^c	20	0.0
	srbc	84	32	5.6^c	18	0.6
	srr	10	5	2.5^c	3	1.0
Superfamily Sra	srab	27	11	2.9^c	5	0.4
Superfamily Srg	srt	72	29	5.8^c	11	0.1
Others
C-type lectins	clec	260	72	4.7^c	44	0.1
F-box	fbxa	220	115	31.5^c	38	0.1
	fbxb	113	43	7.1^c	24	0.6
	fbxc	49	14	1.7	8	0.2
Math, bath, btb	math	50	41	23.6^c	4	0.0
	bath	44	26	9.9^c	9	0.5
	btb	21	8	2.2	4	0.4
Nuclear hormone receptor	nhr	282	71	3.2^c	57	0.5
Pharyngeal gland toxin-related	phat	6	5	4.5^c	0	NA
Scramblase (phospholipid scramblase)	scrm	8	6	4.4^c	0	NA

^aEnrichment (based on DNA-array data) of gene classes in the group of genes with variation linked to isolation site (3,742 genes) and the group of polymorphic genes that were not linked to isolation site (3,965 genes).
^bSignificance in –log10(p).
^cGene classes with group sizes ≥ 6, overlap ≥ 3 genes, and significance ≥ 2.5.

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