Figure 2 From: Low dose pramipexole is neuroprotective in the MPTP mouse model of Parkinson's disease, and downregulates the dopamine transporter via the D3 receptor Histogram of pramipexole's neuroprotective effects against MPTP induced cell loss. Effects of subchronic treatment with pramipexole on total TH-IR cell counts in the substantia nigra and ventral tegmental area of mice treated with or without MPTP. Pramipexole were administered 3 days prior to and during the 2-day treatment with MPTP. Animals survived for 7 days after the last MPTP injection. Data are mean ± standard error of the mean from 4–5 samples per group. * P < 0.05 vs all other groupsBack to article page