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Table 1 List of NMR-visible metabolites assigned in earthworm extracts

From: 'Systems toxicology' approach identifies coordinated metabolic responses to copper in a terrestrial non-model invertebrate, the earthworm Lumbricus rubellus

Compound

Relative concentrationa

Abbreviation

Numberb

Functional classc

Acetate

10

Ac

1

Organic acid

Adenosine

9.3

Ado

2

Nucleoside

ADP

5.9

ADP

3

Energy

Alanine

62

Ala

4

AA

AMP

5.8

AMP

5

Energy

Asparagine

11

Asp

6

Basic AA

Aspartate

5.8

Asp

7

AA

ATP

0.76

ATP

8

Energy

Betaine

11

Bet

9

Membrane

Choline

2.9

Cho

10

Membrane

Dimethylamine

1.7

DMA

11

Other

N,N-dimethylhistidine

5.6

DMH

12

His compound

Fumarate

3.1

Fum

13

Organic acid

Glucose

27

Gluc

14

Sugar

Glucose-6-phosphate

0

G6P

15

Sugar

Glutamate

52

Glu

16

AA

Glutamine

34

Gln

17

Basic AA

Glycine

23

Gly

18

Membrane

HEFS

100

HEFS

19

Membrane

Histidine

2.4

His

20

His compound

Inosine

13

Ino

21

Nucleoside

myo-Inositol

12

m-Ins

22

Membrane

scyllo-inositol

9.9

s-Ins

23

Membrane

Isoleucine

6

Ile

24

Lipophilic AA

Lactate

47

Lac

25

Organic acid

Leucine

17

Leu

26

Lipophilic AA

Lombricine

78

Lom

27

Energy

Lysine

18

Lys

28

Basic AA

Malate

43

Mal

29

Organic acid

Mannose

3.3

Man

30

Sugar

Methionine

1

Met

31

AA

3-Methylhistidine

0.27

3MH

32

His compound

Nicotinate

2.9

Nic

33

Nucleoside

Phenylalanine

7.2

Phe

34

Lipophilic AA

Phosphoethanolamine

21

PE

35

Membrane

Succinate

15

Succ

36

Organic acid

Threonine

10

Thr

37

AA

Tryptophan

2

Trp

38

Lipophilic AA

Tyrosine

6.4

Tyr

39

Lipophilic AA

Uridine

1.3

Uri

40

Nucleoside

Valine

8.9

Val

41

Lipophilic AA

Xanthine

7.2

Xan

42

Nucleoside

  1. aMean value, expressed as a percentage of the most concentrated metabolite (HEFS).
  2. bNumber refers to label in Additional file 1.
  3. cCorresponds to the labels in Figure 2. AA, amino acid.