Figure 1 From: A cryptic promoter in the first exon of the SPG4gene directs the synthesis of the 60-kDa spastin isoform Schematic representation of the SPG4 first exon. Translation of spastin initiates from two in-frame start codons (+1 and +259). A uORF overlaps with the first in-frame AUG and may serve to divert some ribosomes to the downstream start site.Back to article page