Figure 3 From: Docosahexaenoic and eicosapentaenoic acids increase prion formation in neuronal cells The effects of DHA or EPA are not reversed by mevalonate. (A) The amounts of free cholesterol in extracts from ScGT1 cells treated for 7 days with control medium, 5 μM simvastatin (Sim), 1 μM DHA or 1 μM EPA as shown (□), and with the addition of 100 μM mevalonate (■). Values shown are the mean average amounts of free cholesterol (ng/ml) ± SD, n = 9. # = amounts of free cholesterol significantly higher following the addition of mevalonate. (B) The amounts of PrPSc in ScGT1 cells treated for 7 days with control medium, 5 μM simvastatin (Sim), 1 μM DHA, 1 μM EPA as shown (□) and with the addition of 100 μM mevalonate (■). Values shown are the mean average amounts of PrPSc (ng/ml) ± SD, n = 9. # = amounts of PrPSc significantly higher following the addition of mevalonate.Back to article page