Fig. 6
From: TIS7 induces transcriptional cascade of methylosome components required for muscle differentiation
Model of myogenesis regulation by the TIS7/ICln/PRMT5 pathway. In skeletal muscles, TIS7 transcriptionally regulates ICln. The accumulated ICln interacts with PRMT5 and prevents its recruitment to chromatin-bound complexes on the myoD gene. This regulates PRMT5-mediated symmetrical dimethylation of histone H3 Arg8 and myoD expression. The regulated myoD level affects the balance between proliferation and differentiation of MSCs