Fig. 1
From: Exploiting metabolic vulnerabilities for personalized therapy in acute myeloid leukemia
Metabolic pathways relative to deregulated reactions in myeloid leukemia. Enzymes discussed in this review are in blue. Compound abbreviations: F1P fructose-1-phosphate, G1P glucose-1-phosphate, G6P glucose-6-phosphate, F6P fructose-6-phosphate, F1,6BP fructose-1,6-biphosphate, GA3P glyceraldehyde 3-phosphate, DHAP dihydroxyacetone phosphate, 3PG 3-phosphoglycerate, P-Serine phosphoserine, 2PG 2-phosphoglycerate, PEP phosphoenolpyruvate, 6PGL 6-phosphogluconolactone, 6PG 6-phosphogluconic acid, Rib5P ribulose-5-phosphate, X5P xylulose-5-phosphate, R5P ribose-5-phosphate, Sed7P sedoheptulose-7-phosphate, E4P erythrose-4-phosphate, PRPP phosphoribosyl pyrophosphate, Carbamoyl-P carbamoyl phosphate, DHO dihydroorotate, THF tetrahydrofolate, OAA oxaloacetate, α-KG α-ketoglutarate, 2-HG 2-hydroxyglutarate, BCAA branched-chain amino acid