Table 2 Parameters from a non-linear curve fit of ACh concentration–response curves in oocytes expressing Nanorana α4β2 nAChRs

1:3

α4β2(FS)

0.29 (0.18 to 0.49)

102 (63 to 231)

1.4 ± 0.3

1.4 ± 0.4

47.1 ± 3.3

54.7 ± 6.3

9

α4β2(FC)

0.63 (0.30 to 1.40)

935 (92 to ?)

2.0 ± 0.7

0.7 ± 0.6

41.1 ± 9.7

107 ± 150

5

α4β2(LC)

0.41 (0.32 to 0.55)

269 (201 to 530)

1.6 ± 0.2

1.2 ± 0.1

35.0 ± 1.4

79.1 ± 6.5

8

7:1

α4β2(FS)

0.43 (0.29 to 0.64)

117 (92 to 151)

1.5 ± 0.2

1.6 ± 0.2

40.0 ± 1.8

62.2 + 3.5

6

α4β2(FC)

–

–

–

–

–

–

16

α4β2(LC)

0.33 (? to 0.35)

184 (173 to 196)

4.6 ± 1.3

1.7 ± 0.1

38.7 ± 0.2

64.8 ± 0.7

9