Fig. 6

Genomic landscape of ADAR editing events in a cancer cell line. a Flow chart diagram illustrating the process of obtaining true annotated and unannotated editing sites in the K562 cancer cell line. As shown in this study, sites detected only by REDItools and not supported by other methods have to be interpreted with caution due to very low validation ratios. b, c Pie charts showing distributions of true annotated (b) and unannotated (c) editing sites across the indicated genomic elements. The two numbers for each elements represent the number of editing mapping within each element and the fraction of the total sites. d Odds ratios of enrichment of the true annotated K562 sites in various genomic elements. The red dashed line represents the odds ratio of 1. e Sequence motifs around the sites positive or negative in the Sanger validation and all final sites predicted by the pipeline shown in the a–c. The editing site is represented by the position “0.” f Differences in the fraction of each base at each position. The positive values on the Y-axes mean enrichment in the sites positive in the Sanger validation. b–d Only sites with the maximum editing level of > 0.2 across all 130 samples were used in this analysis. Source data are provided as a Source data file