Fig. 1

Innate avoidance of LPS-treated mice requires Trpc2 and Gαi2 but is independent of the V1rab receptor cluster. a Male mice were allowed to investigate two anesthetized male conspecifics injected with either PBS or LPS. Bottom: representative scoring of the sniff episodes. b–e Investigation times and log₂ investigation time ratios (preference score) of PBS/LPS-injected mice for B6, Trpc2^−/−, cGαi2^−/−, and V1rab^−/− mice and their heterozygous controls. b B6 males (mean ± SEM, n = 11). c Trpc2^+/− vs. Trpc2^−/− males (n = 9, each). d Gαi2^+/− vs. cGαi2^−/− males (n = 10, 14, respectively). e V1rab^+/− vs. V1rab^−/− males (n = 10, 12, respectively). Unpaired t-tests, *p < 0.05, **p < 0.01, ***p < 0.001. ns, not significant p = 0.06–0.94. Open circles represent individual mice