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Fig. 6 | BMC Biology

Fig. 6

From: Identification of cell subpopulations associated with disease phenotypes from scRNA-seq data using PACSI

Fig. 6

Application of PACSI on COVID-19 data. A The UMAP visualization of the COVID-19 scRNA-seq dataset. B The UMAP visualization of PACSI-identified cells. The red dots are PACSI-identified cells associated with COVID-19. C The distribution of PACSI-identified cells by cell clusters. D Rank for regulons in PACSI-identified cells associated with COVID-19 based on RSS. E The expression of vital genes in the single-cell data. F The top five Reactome pathways enrichment of genes that were expressed higher in the PACSI-identified cells. G Box plots show the enrichment scores of the COVID-19 signature in the COVID-19 and normal samples from the independent validation dataset. A two-sided Wilcoxon rank-sum test was performed to estimate the significance level

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BMC Biology

ISSN: 1741-7007

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