Table 3 Top 25 most sexually dimorphic CpG sites found in the (A) blood only, (B) placenta only, (C) planceta and blood (blood methylation levels shown). The annotated gene is provided where known

A) Placenta specific

 cg11532947

NAB1

2

3′UTR

5.89E − 122

5.25E − 117

 cg07355069

HMGCS1

5

5′UTR

7.04E − 100

4.71E − 95

 cg25801066

CALM1

14

3′UTR

1.10E − 83

4.89E − 79

 cg18090212

APP

21

3′UTR

9.04E − 72

3.30E − 67

 cg24276949

RIC8B

12

5′UTR

1.48E − 69

5.16E − 65

 cg09102486

5

1.27E − 55

3.09E − 51

 cg17264064

ACAA2

18

1.67E − 52

3.72E − 48

 cg00761634

CHTF8

16

3′UTR

6.38E − 51

1.35E − 46

 cg19473894

CCDC121

2

TSS1500

1.00E − 50

2.02E − 46

 cg11730618

RAB7A

3

TSS1500

1.82E − 50

3.56E − 46

 cg03289961

HADHB

2

ExonBnd

1.72E − 49

3.28E − 45

 cg01440070

SLC6A10P

16

3′UTR

8.10E − 47

1.39E − 42

 cg17968869

SPON1

11

TSS1500

1.90E − 43

2.99E − 39

 cg08721112

1

2.90E − 43

4.40E − 39

 cg07285048

11

TSS1500

4.33E − 43

6.44E − 39

 cg25667734

TERF1

8

TSS1500

4.92E − 41

7.06E − 37

 cg11634496

11

1.09E − 39

1.49E − 35

 cg02343988

11

TSS200

1.61E − 39

2.16E − 35

 cg09779044

CKAP5

11

5′UTR

1.63E − 38

2.08E − 34

 cg18905668

GTF2H1

11

3′UTR

1.21E − 37

1.43E − 33

 cg15604132

ZNF300

5

TSS1500

1.72E − 37

2.00E − 33

 cg27149150

CAMTA1

1

TSS1500

2.60E − 37

2.99E − 33

 cg22846149

HMGB1L1

20

2.88E − 37

3.26E − 33

 cg09914736

CAMTA1

1

3.14E − 36

3.50E − 32

 cg22936497

12

3.39E − 36

3.73E − 32

B) Blood specific

 cg04946709

LOC644649

16

TSS1500

2.23E − 89

7.75E − 85

 cg07585845

3

TSS200

1.25E − 81

3.81E − 77

 cg11284736

HDGFRP3

15

1.10E − 80

3.10E − 76

 cg25742246

1

3′UTR

1.04E − 58

2.12E − 54

 cg16021537

RBMS1

2

1stExon

1.14E − 53

1.94E − 49

 cg03253995

EIF4A1

17

5′UTR

3.20E − 52

5.32E − 48

 cg19311244

4

3′UTR

7.68E − 47

1.08E − 42

 cg11092486

6

1.85E − 45

2.56E − 41

 cg17561891

C7orf23

7

TSS1500

1.91E − 45

2.58E − 41

 cg05812269

RIOK3

18

5′UTR

4.70E − 45

6.24E − 41

 cg24920126

PPP1R3G

6

1stExon

1.46E − 44

1.91E − 40

 cg13045294

LTBP4

19

5′UTR

2.88E − 44

3.69E − 40

 cg07607752

ZPBP2

17

TSS200

2.84E − 43

3.51E − 39

 cg09639931

ZPBP2

17

TSS200

3.07E − 43

3.74E − 39

 cg08528995

SLC35D3

6

4.28E − 43

5.12E − 39

 cg05330360

ZPBP2

17

TSS1500

1.54E − 42

1.76E − 38

 cg09044186

APOA5

11

1.85E − 42

2.08E − 38

 cg03405128

4

3′UTR

4.47E − 42

4.95E − 38

 cg21784396

PRRT4

7

4.02E − 41

4.32E − 37

 cg25294504

20

3′UTR

7.05E − 41

7.47E − 37

 cg26897297

MLNR

13

3′UTR

2.48E − 40

2.55E − 36

 cg11574745

PPP1R3G

6

1stExon

2.84E − 40

2.84E − 36

 cg20808136

15

2.84E − 40

2.84E − 36

 cg07004386

14

3.85E − 40

3.80E − 36

 cg08319905

PPFIA3

19

ExonBnd

8.20E − 40

7.99E − 36

C) Placenta and blood overlap

 cg26919182

PPP1R12B

1

5′UTR

1.68E − 253

1.23E − 247

 cg12691488

1

6.27E − 221

2.29E − 215

 cg15228509

1

4.91E − 212

1.20E − 206

 cg06513015

ERV3-1

7

5′UTR

1.69E − 194

3.09E − 189

 cg00148935

RFTN1

3

3′UTR

2.10E − 176

3.07E − 171

 cg09516963

DYRK2

12

TSS1500

3.03E − 171

3.69E − 166

 cg11643285

RFTN1

3

3′UTR

1.13E − 167

1.18E − 162

 cg03626220

HYDIN

16

2.66E − 144

2.43E − 139

 cg26355737

TFDP1

13

4.90E − 127

3.98E − 122

 cg03226871

2

5′UTR

3.17E − 125

2.31E − 120

 cg02716779

DNM1

9

3′UTR

3.08E − 124

2.04E − 119

 cg02325951

FOXN3

14

1stExon

1.12E − 119

6.79E − 115

 cg12607525

UBTF

17

2.30E − 119

1.29E − 114

 cg20262915

NAB1

2

1stExon

7.43E − 116

3.88E − 111

 cg20299935

17

8.80E − 115

4.29E − 110

 cg19765154

NAB1

2

1stExon

4.63E − 114

2.11E − 109

 cg23719534

15

3′UTR

1.40E − 110

6.03E − 106

 cg03618918

1

1.02E − 105

4.15E − 101

 cg17238319

RFTN1

3

2.33E − 105

8.97E − 101

 cg17232883

11

8.96E − 98

3.27E − 93

 cg07852945

TLE1

9

TSS1500

8.89E − 85

2.95E − 80

 cg17612569

GABPA

21

5′UTR

4.35E − 82

1.38E − 77

 cg02989351

YWHAQ

2

1stExon

7.40E − 81

2.16E − 76

 cg03218192

AP2B1

17

1stExon

4.57E − 79

1.24E − 74

 cg09696045

15

TSS1500

9.09E − 78

2.37E − 73