Fig. 5
From: A stromal lineage maintains crypt structure and villus homeostasis in the intestinal stem cell niche
Intestinal Twist2 cell-secreted Wnts were critical for crypt regeneration. a H/E, Ki67, goblet, and Paneth cell staining of intestinal villi of control and Twist2-Cre;Wls+/f mice 4 or 7 days after IR (6.5 Gy). Bar: 50 μm. Right panels: quantitation data. *P < 0.05, **P < 0.01, and ***P < 0.001. N = 4. b Acta2-Cre; Wlsf/f mice showed a defect in crypt regeneration 4 days after IR. H/E, Ki67, and goblet cell staining of intestinal villi of control and Acta2-Cre; Wls.f/f mice 4 days after IR (6.5 Gy). Bar: 50 μm. Right panels: quantitation data. *P < 0.05, **P < 0.01, and***P < 0.001. N = 5