Fig. 6

Crossovers are directed away from AT-rich isochores and genes. A UCSC genome browser screenshot of human KRTAP cluster showing recombination rates (maternal meiosis in red, paternal meiosis in blue) and PRDM9 binding calls (black). B Manhattan plot of standardized maternal (above 0) and paternal (below 0) recombination rate for each gene with its 25-kb flanking regions. Genes are colored according to the GC content of their home isochore (Red: high AT. Blue: high GC). Scale bars: 10 Mb. Chromosome ideograms reflect centromeres (bright red), gaps (dark red) and Giemsa bands (grays). Recombination rates are low for genes located in AT-rich isochores, except at chromosome ends, which are depleted for maternal recombination. C Maternal and D paternal crossover rates in isochores binned by GC percent. Crossover calls are from deCODE [92]. E PRDM9 peak enrichment across isochores binned by GC%. F, G Scatterplot of tandem neighbor counts per genes within the same isochore versus F the sum of maternal and paternal standardized relative recombination and G sum PRDM9 enrichment