Fig. 5

Chemogenetic activation of PrL excitatory neurons improved the WMC of 5XFAD mice. a Schematic diagram (coronal section) showing the injection target of the virus (hM3Dq-mCherry or mCherry) in the PrL. B The minimal injected current to induce action potential (Paired Student’s t test, p = 0.13). n = 8. c The number of induced action potentials at different current steps (Two-way ANOVA, **p < 0.01). d Current–voltage relationship of a representative PrL neuron recorded before and during CNO perfusion. e The WMC of mice in the mCherry and hM3Dq group (Unpaired Student’s t test, *p < 0.05). mCherry: n = 5; hM3Dq: n = 6. f Percent correct at each capacity level of mice in the mCherry and hM3Dq group (Two-way ANOVA, ****p < 0.0001). g Percentage of mice succeeded at each capacity level in the mCherry and hM3Dq group (Two-way ANOVA, ****p < 0.0001). h The WMC of mice in the test phase before and during CNO perfusion (Paired Student’s t test, *p < 0.05). n = 6. i Percent correct at each capacity level of mice before and during CNO perfusion (Two-way ANOVA, ****p < 0.0001). j Percentage of mice succeeded at each capacity level before and during CNO perfusion (Two-way ANOVA, ****p < 0.0001). Data are presented as the mean ± SEM