Fig. 1
From: Regulatory changes associated with the head to trunk developmental transition
Transcriptomic changes in the posterior epiblast associated with the head to trunk transition. A Schematic representation of sample collection from the posterior epiblast region of mouse embryos at E7.5 and E8.5. B Volcano plot of RNA-seq gene expression (|Log2(Fold Change)|≥ 1 & p-value < 0.05). Significantly upregulated genes at E8.5 are in red, downregulated at E8.5 are in green and non-significant in black. C-D Gene expression of key pluripotent and early developmental genes (C) and Hox genes (D). E K-means clustering of the 1000 most variable genes. Cluster 1: 616 genes; Cluster 2: 352 genes; Cluster 3: 32 genes. F Top 3 GO terms from biological processes associated with Cluster 1, 2 and 3