Fig. 2
From: Regulatory changes associated with the head to trunk developmental transition
Interaction networks reveal changes in various functional modules. A Protein–protein interaction network based on the differentially expressed genes between E7.5 and E8.5. Colored clusters represent structurally coherent network modules identified using LowEnDe [40]. Purple cluster, Growth factors; Green cluster, Lipoprotein metabolism; Yellow cluster, Immune system. B-D Expanded versions of the Hox (B), Wnt (C), ubiquitination (D) and G-protein coupled receptor signaling (E) modules are shown to highlight the genes included in each. Nodes are colored by Log2(Fold Change), node size by Log2(CPM). Significantly upregulated genes at E8.5 are in red, downregulated genes at E8.5 are in blue