Fig. 7

Impact of RA signaling in genome accessibility of the posterior epiblast. A Volcano plot of ATAC-seq peaks (Raldh2^−/− vs WT) (|Log₂(Fold Change)|> 2 & p-value < 0.05). Significantly open regions in Raldh2^−/− are red, closed regions in Raldh2^−/− are green and non-significant in black. B Genomic distribution of ATAC-seq peaks identified in WT (blue), Raldh2^−/− (gray) and distribution of only the differentially accessible peaks (black). C-H Average ATAC-seq profiles of RARα (C), RARβ (D), RARγ (E), RXRα (F), RXRβ (G) and RXRγ (H) binding sites. Blue profiles correspond to wild type, gray profiles to Raldh2^−/−, n indicates the number of binding sites used to calculate the average profiles