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Fig. 6 | BMC Biology

Fig. 6

From: Differential functions of RhoGDIβ in malignant transformation and progression of urothelial cell following N-butyl-N-(4-hydmoxybutyl) nitrosamine exposure

Fig. 6

PP2A/JNK axis mediated c-Jun protein phosphorylation and its targeted gene RhoGDIβ transcription, as well as cell invasion. A Whole-cell lysates from indicated cells were analyzed for both total protein level and activation levels of JNK and PP2A using Western blot. GAPDH was used as a protein loading control. B Indicated cells were treated with okadaic acid (OA) for 6 h, and then whole-cell lysates were evaluated for protein expression by Western blot as indicated. β-Actin was used as a protein loading control. C Whole-cell lysates from indicated cells were analyzed for protein expression and activation by Western blot as indicated. β-Actin was used as a protein loading control. D, E UROtsaBBN6mo/Nonsense and UROtsaBBN6mo/shPP2A-C transfectants were subjected to transwell invasion assay. The asterisk indicates significant difference in comparison to UROtsaBBN6mo/Nonsense cells

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BMC Biology

ISSN: 1741-7007

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