Fig. 1

HIIT stimulates lactate secretion to induce fat loss. A The level of blood lactate before and after exercise for 0, 5, 15, 30, and 60 min. Data are shown as mean ± SD, n = 7–10. B Body weight of mice under different intervention methods. C–E The ratio of iWAT, eWAT, and BAT weight to body weight in mice. F Food intake of CON, HIIT, and DCA + HIIT mice was monitored. G H&E staining results for iWAT, eWAT, and BAT (40X). H, I Quantification of the average cross-sectional area of iWAT and eWAT. Data are shown as mean ± SD, n = 10, *p < 0.05; **p < 0.01; ***p < 0.001. HIIT high-intensity interval training, DCA + HIIT dichloroacetate injection + high-intensity interval training, iWAT subcutaneous adipose tissue, eWAT visceral adipose tissue, BAT brown adipose tissue