Fig. 3

Splicing and expression regulate distinct biological processes. A The number of gene sets significantly enriched among genes from either analysis across comparisons. B Results from the Tian et al. [26] study showing the gene-set enrichment scores of gene sets enriched among the differentially spliced (x-axis) and differentially expressed (y-axis) genes. Only gene sets significantly enriched among differentially spliced or differentially expressed genes (indicated by color) are shown. The shape highlights gene sets where the name contains the word “telomer.” Spearman’s correlation is indicated in the lower left corner. C Histogram of the Spearman’s correlations between gene-set enrichment scores for gene sets significantly enriched among differentially expressed or spliced genes. D For each comparison, we calculated the median differences between the relative risks of gene sets enriched among differentially expressed and spliced genes as the percent change of the smallest risk score