Fig. 2

Integrative co-expression analysis of unfractionated RNAseq reveals enriched genes in human stomach cell types. (A) Total number and proportional representation of class for cell type enriched genes in: (i) gastric mucous cells, (ii) plasma cells, (iii) fibroblasts, (iv) mitotic cells, (v) macrophages, (vi) parietal cells, (vii) chief cells, (viii) endothelial cells, (ix) gastric enteroendocrine cells, (x) T-cells and (xi) neutrophils. (cells, (viii) endothelial cells, (ix) gastric enteroendocrine cells, (x) T-cells and (xi) neutrophils. (B) RNAseq data for) RNAseq data for 359 unfractionated human stomach samples was subject to weighted correlation network analysis (WGCNA). (i) Coloured squares indicate cell type Ref.T. positions on resultant dendrogram. (ii) Coloured bars show distribution of protein coding genes classified as cell type-enriched across dendrogram groups. (C) Human stomach tissue profiling for proteins encoded by genes classified as: (i) gastric enteroendocrine cell, (ii) mitotic cell, (iii) parietal cell, (iv) chief cell or (v) gastric mucous cell enriched. (D) Over-represented gene ontology terms among genes predicted to be (i) gastric enteroendocrine cell, (ii) parietal cell or (iii) gastric mucous cell enriched. See also Table S1 Tab 2, 3, 5 and 6