Fig. 6

Core non-coding gene signatures of human stomach cell types and tissue distribution patterns. Non-coding gene enrichment signatures for: (A) parietal cells, (B) chief cells, (C) plasma cells and (D) endothelial cells, detailing (i) up to 25 examples of cell type enriched non-coding genes, ordered by correlation coefficient with the Ref.T. panel, showing differential correlation scores (correlation with corresponding cell type Ref.T., panel minus max correlation with any other Ref.T. panel), mean expression in bulk RNAseq and gene type. (ii and iii) scRNAseq data from analysis of epithelial, endothelial, immune, or stromal cell compartments across 24 human tissues was sourced from Tabula Sapiens (Tabula Sapiens et al., 2022), and used to generate UMAP plots showing the expression profiles of example cell type enriched non-coding genes. The largest plot shows the compartment with the highest expression. (E) The most highly expressed cell type enriched non‐coding genes in stomach bulk RNAseq. (F) Expression of genes classified as enriched in parietal cells: (i) LINC00982 and (ii) PP7080, plasma cells: (iii) IGLC6, gastric mucous cells: (vi) FER1L4 and (v) RP11-363E7.4, fibroblasts: (vi) HSPA7 and chief cells: (vii) C9orf147, in bulk RNAseq of different human organs. Mean TMP expression is annotated for selected organs on each plot. See also Table S1 Tab 2 and Figure S2 (for all UMAP plot annotations)