Fig. 3
K525N&F627Y is inhibited by dofetilide and E4031. a Representative currents of K525N&F627Y with or without 10 μM dofetilide. Inward currents were elicited with -135 mV (the protocol see below). b histogram of I/I0 at -135mV with or without dofetilide (n≥6). c I-V curves of K525N&F627Y with or without dofetilide (n≥6). d Representative currents of K525N&F627Y with or without 3 μM E4031. e histogram of I/I0 at -135mV with or without E4031 (n≥6). f I-V curves of K525N&F627Y with or without E4031 (n≥6). g Representative step currents of K525N&F627Y with or without dofetilide. The step voltage protocol (below) varies from -165 to +30 mV. h The G-V curve (n≥6) and i V1/2 values (n≥6) of K525N&F627Y with or without dofetilide. j Representative step currents of K525N&F627Y with or without E4031. k The G-V curve (n≥6) and l V1/2 values (n≥6) of K525N&F627Y with or without E4031. Error bars represent mean ± SEM. *P<0.05, **P<0.01; ***P<0.001, two-tailed Student’s t-test