Table 2 Germline transmission data for the 12 projects bred to the F1 generation
From: Donor template delivery by recombinant adeno-associated virus for the production of knock-in mice
Project | No. of founders bred | No. of founders producing litters | No. of founders which transmitted a validated F1 | No. of founders which transmitted a validated F1 in 1st litter | No. of F1s from transmitting founder tested | No. of heterozygous F1 |
|---|---|---|---|---|---|---|
GMAJ | 4 | 4 | 3 | 3 | 24 | 9 |
GMAF | 3 | 3 | 3 | 3 | 18 | 8 |
GMAL | 4 | 3 | 2 | 2 | 27 | 6 |
GMAM | 2 | 2 | 1 | 1 | 18 | 4 |
IRDB | 1 | 1 | 1 | 1 | 10 | 5 |
RLEB | 3 | 3 | 3 | 2 | 27 | 15 |
IRCU | 3 | 3 | 3 | 3 | 21 | 5 |
GMAG | 2 | 2 | 2 | 2 | 17 | 11 |
GMAN | 4 | 4 | 1 | 1 | 11 | 11 |
GMAZ | 2 | 2 | 2 | 1 | 18 | 9 |
GMAW | 3 | 3 | 2 | 2 | 15 | 5 |
GMAR | 1 | 1 | 1 | 1 | 3 | 2 |
Totals | 31 | 30 | 23 (76.7%) | 21 (91.3%) | 207 | 90 (43.5%) |