Fig. 9
Model figure. RPSA translocation from the intracellular environment (cytosol) to the cell surface in the form of liquid-like condensates driven by its IDR. ENO binds to the IDR of RPSA and promotes its interaction with RPSA and VIM on cell membrane. The incorporation and concentration of ENO-RPSA-VIM complexes increase the cellular Ca2+ level, and consequently promotes the RPSA condensate formation and induces HBMEC apoptosis. Images were created with Biorender.com