Table 1 Cohort characteristics
Cancer type | n | Sample type | n | MSI/MSS status | n | POLE status | n |
|---|---|---|---|---|---|---|---|
Breast | 126 | FFPE | 60 | MSI | 3 | POLE mut | 1 |
Frozen | 66 | MSS | 123 | POLE WT | 125 | ||
Colorectal | 72 | FFPE | 52 | MSI | 14 | POLE mut | 1 |
Frozen | 20 | MSS | 58 | POLE WT | 71 | ||
Sarcoma | 72 | FFPE | 40 | MSS | 72 | POLE WT | 72 |
Frozen | 32 | ||||||
Ovarian | 59 | FFPE | 41 | MSI | 3 | POLE mut | 1 |
Frozen | 18 | MSS | 56 | POLE WT | 58 | ||
CNS tumor | 58 | FFPE | 19 | MSS | 58 | POLE WT | 58 |
Frozen | 39 | ||||||
Pancreatic carcinoma | 42 | FFPE | 35 | MSI | 2 | POLE WT | 42 |
Frozen | 7 | MSS | 40 | ||||
Endometrial | 28 | FFPE | 17 | MSI | 4 | POLE WT | 28 |
Frozen | 11 | MSS | 24 | ||||
Thyroid | 20 | FFPE | 18 | MSS | 20 | POLE WT | 20 |
Frozen | 2 | ||||||
HNSCC | 19 | FFPE | 15 | MSS | 19 | POLE WT | 19 |
Frozen | 4 | ||||||
Lymphoma | 18 | Frozen | 18 | MSS | 18 | POLE WT | 18 |
Cholangiocarcinoma | 17 | FFPE | 12 | MSS | 17 | POLE WT | 17 |
Frozen | 5 | ||||||
Lung | 17 | FFPE | 8 | MSS | 17 | POLE WT | 17 |
Frozen | 9 | ||||||
Cervical | 13 | FFPE | 10 | MSS | 13 | POLE WT | 13 |
Frozen | 3 | ||||||
ACUP | 12 | FFPE | 5 | MSI | 1 | POLE WT | 12 |
Frozen | 7 | MSS | 11 | ||||
Rhabdoid tumor | 11 | FFPE | 2 | MSS | 11 | POLE WT | 11 |
Frozen | 9 | ||||||
Anal | 10 | FFPE | 7 | MSS | 10 | POLE WT | 10 |
Frozen | 3 | ||||||
Gastric | 10 | FFPE | 5 | MSS | 10 | POLE WT | 10 |
Frozen | 5 | ||||||
Adenoid cystic carcinoma | 8 | FFPE | 5 | MSS | 8 | POLE WT | 8 |
Frozen | 3 | ||||||
Bladder | 7 | FFPE | 2 | MSS | 7 | POLE WT | 7 |
Frozen | 5 | ||||||
Mesothelioma | 7 | FFPE | 3 | MSS | 7 | POLE WT | 7 |
Frozen | 4 | ||||||
Vaginal | 6 | FFPE | 3 | MSS | 6 | POLE WT | 6 |
Frozen | 3 | ||||||
Prostate | 5 | FFPE | 3 | MSS | 5 | POLE WT | 5 |
Frozen | 2 | ||||||
Uveal melanoma | 5 | Frozen | 5 | MSS | 5 | POLE WT | 5 |
Cutaneous melanoma | 4 | FFPE | 2 | MSS | 4 | POLE WT | 4 |
Frozen | 2 | ||||||
Sex chord tumor | 4 | FFPE | 3 | MSS | 4 | POLE WT | 4 |
Frozen | 1 | ||||||
Appendix | 3 | FFPE | 3 | MSS | 3 | POLE WT | 3 |
Esophageal | 3 | FFPE | 1 | MSS | 3 | POLE WT | 3 |
Frozen | 2 | ||||||
Salivary gland tumor | 3 | FFPE | 3 | MSS | 3 | POLE WT | 3 |
UCNT | 3 | FFPE | 3 | MSS | 3 | POLE WT | 3 |
GIST | 2 | FFPE | 2 | MSS | 2 | POLE WT | 2 |
Neuroendocrine | 2 | FFPE | 1 | MSS | 2 | POLE WT | 2 |
Frozen | 1 | ||||||
Renal | 2 | Frozen | 2 | MSS | 2 | POLE WT | 2 |
Vulva | 2 | FFPE | 2 | MSS | 2 | POLE mut | 1 |
POLE WT | 1 | ||||||
Craniopharyngioma | 1 | FFPE | 1 | MSS | 1 | POLE WT | 1 |
Cutaneous SCC | 1 | FFPE | 1 | MSS | 1 | POLE WT | 1 |
Duodenal carcinoma | 1 | FFPE | 1 | MSS | 1 | POLE WT | 1 |
Hepatoblastoma | 1 | FFPE | 1 | MSS | 1 | POLE WT | 1 |
Leiomyosarcoma | 1 | Frozen | 1 | MSS | 1 | POLE WT | 1 |
Peritoneum | 1 | FFPE | 1 | MSS | 1 | POLE WT | 1 |
Small bowel carcinoma | 1 | FFPE | 1 | MSI | 1 | POLE WT | 1 |
Thymoma | 1 | FFPE | 1 | MSS | 1 | POLE WT | 1 |
Waldenstrom | 1 | Frozen | 1 | MSS | 1 | POLE WT | 1 |
Other | 6 | FFPE | 4 | MSS | 6 | POLE WT | 6 |
Frozen | 2 |